磷酸咯萘啶及其合并双氢青蒿素治疗疟疾效果观察

目的观察国产抗疟药磷酸咯萘啶单方和磷酸咯萘啶合并双氢青蒿素在厄利特里亚治疗疟疾的近期疗效.方法以显微镜血检疟原虫阳性者为观察对象,服药后逐日血检疟原虫,观察治疗效果.结果单方治疗间日疟与恶性疟的原虫平均转阴时间分别为32.00 h和50.18 h;联合治疗间日疟与恶性疟的原虫平均转阴时间分别为24.00 h和27.69 h;联合治疗抗氯喹恶性疟平均转阴时间为24.00h.两组药物治疗的病人均于治疗结束前体温恢复正常.未见明显副反应.首次治疗后7 d,单方组有55.56%的恶性疟病例携带配子体,高于联合用药的18.18%.结论联合用药优于单用,但两组药物对当地疟疾均100%临床治愈,有良好的近期疗效.

OBSERVATION ON EFFICACY OF PYRONARIDINE PHOSPHATE AND IT COMBINED WITH DIHYDROARTEMISININ FOR TREATMENT OF MALARIA IN ERITREA, AFRICA

Objective To observe the short-term efficacy of the domestic anti-malaria drugs pyronaridine phosphate and pyronaridine phosphate combined with dihydroartemisinin for treatment of malaria in the state of Eritrea. Methods People with plasmodium were selected as the subjects and were followed up daily by blood examination after they took the drugs. Results The mean asexual clearance time of Plasmodium vivax and P. falciparum was 32.00 h and 50.18 h after the single-drug therapy respectively and 24.00 h, and 27.69 h after the combined-drug therapy respectively. As to the chloroquine resistant falciparum malaria cases, the mean asexual clearance time of the combined-drug therapy was 24 h. The fever of all 36 cases stopped before the finish of the treatment. The adverse reaction was mild and transient. On the 7th day after the 1st dose in the single-drug therapy, gametocytes were found in the blood of 55.56% falciperum malaria cases, higher than the 18.18% in the combined-drug therapy. Conclusion Both therapeutic methods showed the 100% cure rate in Eritrea although the combined-drug therapy seemed more effective than the single-drug therapy.