川芎嗪对体外循环心内直视手术患者心肌保护的临床研究

目的 探讨川芎嗪对体外循环心内直视手术患者心肌保护的效果。方法 １２例风湿性瓣膜病患者，随机分为对照组和用药组，每组６你，用药组在体外循环预充液中加入盐酸川芎嗪３ｍｇ．ｋｇ＾－１，ＢＷ＾－１，观察了术前、术后及术后７２ｈ患者血流动力学变化及血液中肌酸磷酸激酶（ＣＰＫ）和肌酸磷酸激酶同功酶（ＣＰＫ－ＭＢ）含量变化。结果 用药组术后各项血流动力学指标优于对照组，血液中ＣＰＫ、ＣＰＫ－ＭＢ含量在术后１２

Cardiac Protective Effects of Tetramethylpyrazine in Patients Performed Open Heart Operation with Cardiopulmonary Bypass

Objective: To study the cardiac protective effects of tetramethylpyrazine (TMP) on patients undergoing cardiac operation. Methods: Twelve patients with rheumatic heart disease were randomly divided into the TMP group and the control group, 6 in each group. The changes of hemodynamics, serum creatine phosphokinase (CPK), creatine phosphokinase isoenzyme (CPK MB) levels were observed before, during and 72 hours after operation. Results: The hemodynamic indexes in the TMP group were better than those in the control group after operation, the serum CPK, CPK MB levels measuring 12h, 24h and 48h after operation in the TMP group were lower than those in the control group. Conclusion: TMP has good cardiac protective function in patients undergoing cardiac operation in improving cardial function and reducing the release of myocardial enzymes.