利培酮与舒必利治疗急性脑血管疾病后妄想综合征比较

目的:观察利培酮治疗急性脑血管疾病后妄想综合征的疗效。方法:急性脑血管疾病后妄想综合征病人100例,分为2组,利培酮组50例,男性27例,女性23例,年龄(64±s11)a,给予利培酮0.5mg·d-1,逐渐加至1.5～2.0mg·d-1,po×4wk;舒必利组50例,男性26例,女性24例,年龄(65±12)a,给予舒必利0.3g·d-1,逐渐加至0.5～0.6g·d-1,po×4wk。结果:利培酮组和舒必利组经过4wk的治疗后总有效率分别为86%和82%(P>0.05),2组在wk2末有效率分别为74%和24%(P<0.05)。结论:利培酮治疗急性脑血管疾病后妄想综合征与舒必利对比显效早、药物不良反应少且轻。

Risperidone vs sulpiride in treating delusional syndrome after acute cerebral vascular disease

AIM: To observe the effects of risperidone for curing delusions syndrome after acute cerebral vascular diseasel (ACVD). METHODS:One hundred patients with ACVD were divided into two groups; risperidone group consisting 50 patients, (M 27,) F 23,age (64±s 11) a, were given risperidone (0.5 mg·)d~(-1) with gradual increase dosage of 1.5-(2.0 mg·)d~(-1),po×4 wk;sulpiride group of 50 patients, (M 26,) F 24,age(65±12) a,were given sulpiride (0.3 g·)d~(-1)also with gradual increase of dosage into 0.5-(0.6 g·)d~(-1), po×4 wk. RESULTS:After 4 wk,the general effective rates of risperidone group and sulpiride group were 86 % and 82 %,respectively (P>0.05),those of two groups by the end of (2 wk) were 74 % and 24 %,respectively (P<0.05). CONCLUSION:Delusional syndrome disappearing after ACVD with risperidone is earlier than sulpiride with more effective results and less adverse reactions.