| 蒿甲醚、吡喹酮早期治疗感染血吸虫病病兔的肝脏病理变化 |
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| 引用本文： | 张超威,杨元清,肖树华.蒿甲醚、吡喹酮早期治疗感染血吸虫病病兔的肝脏病理变化[J].中国寄生虫学与寄生虫病杂志,1995(1). |
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| 作者姓名： | 张超威 杨元清 肖树华 |
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| 作者单位： | 中国预防医学科学院寄生虫病研究所，世界卫生组织疟疾、血吸虫病和丝虫病合作中心 |
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| 基金项目： | 世界银行贷款中国血吸虫病控制项目联合科研管理委员会（JRMC）部分资助,八五攻关课题 |
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| 摘 要： | 兔于感染日本血吸虫尾蚴后ｄ７灌服（ｉｇ）１次蒿甲醚（Ａｒｔ）３０ｍｇ·ｋｇ－１，并于感染后ｄ１４、ｄ２１、ｄ３５和ｄ４９重复ｉｇ１次相同剂量的Ａｒｔ时，在兔肝的切片中仅查见死虫，未见有虫卵或和虫卵性肉芽肿形成。若于感染后ｄ７、ｄ２１、ｄ３５和ｄ４９ｉｇ上述剂量的Ａｒｔ１次时，肝内偶而查见少量虫卵和虫卵性肉芽肿。若于感染后ｄ２１ｉｇ１次吡喹酮（Ｐｒａ）４０ｍｇ·ｋｇ－１，然后每ｗｋ（ｄ２８和ｄ３５）或每２ｗｋ（ｄ３５和ｄ４９）重复ｉｇ１次相同剂量的Ｐｒａ时，前者肝切片查见的虫卵数和虫卵肉芽肿远较对照组的为少，但较后者为多，后者所查见的为陈旧性虫卵或虫卵性芽肿。结果表明兔于感染血吸虫尾蚴后，用Ａｒｔ或Ｐｒａ早期治疗，因大部分或甚至全部♀虫被杀死，肝脏受虫卵损害轻微或无明显损害。
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| 关 键 词： | 日本血吸虫 虫卵肉芽肿 蒿甲醚 吡喹酮 |
PATHOLOGICAL CHANGES IN THE LIVERS OF RABBITS INFECTED WITH SCHISTOSOME CERCARIAE AND TREATED WITH ARTEMETHER OR PRAZIQUANTEL IN THE EARLY STAGE OF INFECTION |
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| Zhang Chaowei,Yang Yuanqing,Xiao Shuhua Institute of Parasitic Diseases,Chinese Academy of Preventive Medicine,WHO Collaborating Centre for Malaria,Schistosomiasis and Filariasis.PATHOLOGICAL CHANGES IN THE LIVERS OF RABBITS INFECTED WITH SCHISTOSOME CERCARIAE AND TREATED WITH ARTEMETHER OR PRAZIQUANTEL IN THE EARLY STAGE OF INFECTION[J].Chinese Journal of Parasitology and Parasitic Diseases,1995(1). |
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| Authors: | Zhang Chaowei Yang Yuanqing Xiao Shuhua Institute of Parasitic Diseases Chinese Academy of Preventive Medicine WHO Collaborating Centre for Malaria Schistosomiasis and Filariasis |
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| Institution: | Zhang Chaowei,Yang Yuanqing,Xiao Shuhua Institute of Parasitic Diseases,Chinese Academy of Preventive Medicine,WHO Collaborating Centre for Malaria,Schistosomiasis and Filariasis. Shanghai 200025 |
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| Abstract: | |
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| Keywords: | Schistosoma japonicum egg granuloma artemether praziquantel |
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