脾切除后血小板聚集及ATP释放增高机制的探讨

测定了32例脾切除患者血小板聚集(PAg),其中包括16例同步测定PAg及ATP释放(ATP-R)的结果。脾切除组由ADP、Coll及ADR所致5分钟内最大聚集率(M~1)及ATP-R的均值较脾切除前组及正常对照组均有一定程度升高,其中以肝硬化代偿期脾切除组升高最明显(P<0.05～0.001)。其发生机制与血小板数增多、凝血因子增加、抗凝活性减低、继发性纤溶活性增加及血小板代谢活性指标TXB_2增高等因素有关,提示脾切除患者PAg及ATP-R升高与临床存在的高凝状态有关。

The Exploration of Pathogenesis of Hyperaggregation and Hyper-ATP-Release (ATP-R) After Splenectomy

The platelet aggregation test (PAgT) were assayed in 32 patients after splenectomy in which ATP-R were assayed simultaneously in 16 patients. The mean value of the maximal rates within 5 minutes of PAgT and ATP-R were increased to a certain degree, especially in compensatory stage of the liver cirrhosis ( P < 0. 05-0. 001). The pathogenesis of hyperaggregation and hyper-ATP-R after splenectomy might be associated with thrombocytosis, increased coagula-ble factors, decreased anticoagulable activity. It was suggested that the hyperaggregation and hyper-ATP-R after splenectomy were correlated with the presence of hypercoagulability.