| 七氟醚抑制突触后胆碱能突触传递而不影响短时程增强 |
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| 引用本文： | Hiroaki Naruo,Shin Onizuka,David Prince,Mayumi Takasaki,Naweed I.Syed,方波,王俊科.七氟醚抑制突触后胆碱能突触传递而不影响短时程增强[J].国际麻醉学与复苏杂志,2005,26(3):189. |
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| 作者姓名： | Hiroaki Naruo Shin Onizuka David Prince Mayumi Takasaki Naweed I.Syed 方波 王俊科 |
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| 作者单位： | Research Associate,Department of Anesthesiology, Miyazali Medical College;Research Associate Cellular and Molecular Neurobiology Research Group,Faculty of Medicine, University of Calgary;Graduate Student Cellular and Molecular Neurobiology Research Group,Faculty of Medicine, University of Calgary;Professor,Department of Anesthesiology, Miyazali Medical College;Professor, Cellular and Molecular Neurobiology Research Group,Faculty of Medicine, University of Calgary;中国医科大学第一临床学院麻醉科 |
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| 摘 要： | 背景:目前人们已了解全身麻醉对兴奋性和抑制性突触的作用。但全身麻醉影响突触可塑性,从而影响学习和记忆的机制在细胞水平上尚不清晰。本研究选取体细胞-体细胞之间一致的突触后神经元,验证临床浓度的七氟醚是否影响胆碱能突触传递的短时程增强。方法:选择软体动物Lymnaea(椎旁螺属)stagna lis,在完整的神经节上分离独特的神经元,内脏背4(突触前)和左足背1(突触后)。用一夜时间配成体细胞间结构。对照组和七氟醚组均用FM1-43染色荧光影像在细胞内即刻记录。结果:神经元之间的胆碱能突触传递表现出经典的短时程强直后增强。七氟醚浓度依…
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Sevoflurane blocks cholinergic synaptic transmission postsynaptically but does not affect short-term potentiation |
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| Hiroaki Naruo,Shin Onizuka,David Prince,Mayumi Takasaki,Naweed I.Syed.Sevoflurane blocks cholinergic synaptic transmission postsynaptically but does not affect short-term potentiation[J].international journal of anesthesiology and resuscitation,2005,26(3):189. |
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| Authors: | Hiroaki Naruo Shin Onizuka David Prince Mayumi Takasaki Naweed ISyed |
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