L-精氨酸对急性冠脉综合征患者血管内皮功能的影响

目的评价L-精氨酸对急性冠脉综合征患者血管内皮功能的影响。方法97例急性冠脉综合征患者被随机分到对照组、维生素C治疗组和L-精氨酸治疗组。所有患者分别于入院时及用药3周后取静脉血,测定血浆一氧化氮(NO)、内皮素-1(ET-1)、C-反应蛋白(CRP)和脂蛋白(a)Lp(a)]的浓度。结果治疗3周后,L-精氨酸治疗组NO高于对照组(P<0.05),ET-1、CRP、Lp(a)低于对照组(P<0.01)。结论L-精氨酸能够改善急性冠脉综合征患者血管内皮功能。

Effect of L-arginine on endothelial function in patients with acute coronary syndromes

Objective To evaluate the effect of L-arginine on endothelial function in patients with acute coronary syndromes(ACS).Methods 97 patients with ACS were randomized to receive routine therapy(placebo group) or routine therapy and Vitamin C treatment(Vitamin C treated group)or routine therapy and L-arginine treatment(L-arginine treated group).Blood samples were taken before and after administration of the trial drug,plasma Nitric oxide(NO)?Endothelin-1(ET-1)?C-reactive protein(CRP) and Lipoprotein(a) Lp(a)] were detected. Results Three weeks later, the level of NO in L-arginine treated group was higher than that in placebo group(P<0.05=,while the levels of ET-1?CRP and Lp(a) were lower than those in placebo group(P<0.01=. Conclusion L-arginine can improve the endothelial function in patients with ACS.