| 白细胞介素—2及其受体与乙型肝炎疫苗接种无、弱应答发生的关系 |
| |
| 引用本文： | 谢婧王学良,庄贵华徐慧文郝炳华,谢婧王学良,庄贵华徐慧文郝炳华,唐晓红吴谦. 白细胞介素—2及其受体与乙型肝炎疫苗接种无、弱应答发生的关系[J]. 中华肝脏病杂志, 2000, 8(6): 332-334 |
| |
| 作者姓名： | 谢婧王学良 庄贵华徐慧文郝炳华 谢婧王学良 庄贵华徐慧文郝炳华 唐晓红吴谦 |
| |
| 作者单位： | 谢婧（西安医科大学流行病学教研室西安 710061） 王学良（西安医科大学流行病学教研室西安 710061） 庄贵华（西安医科大学流行病学教研室西安 710061） 徐慧文（西安医科大学流行病学教研室西安 710061） 郝炳华（西安医科大学流行病学教研室西安 710061） 谢婧（西安医科大学流行病学教研室 西安,710061） 王学良（西安医科大学流行病学教研室 西安,710061） 庄贵华（西安医科大学流行病学教研室 西安,710061） 徐慧文（西安医科大学流行病学教研室 西安,710061） 郝炳华（西安医科大学流行病学教研室 西安,710061） 唐晓红（西安医科大学流行病学教研室 西安,710061） 吴谦（西安医科大学流行病学教研室 西安,710061） |
| |
| 摘 要： |
|
| 关 键 词： | 乙型肝炎疫苗 白细胞介素－2 IL－2 sIL－2R 乙型肝 |
| 修稿时间： | 1999-11-01 |
Relationsjip between interleukin-2,interleukin-2 receptor and the non-and hypo-responsivencess to hepatitis B vaccine |
| |
| J Xie,X Wang,G Zhuang,H Xu,B Hao,X Tang,Q Wu. Relationsjip between interleukin-2,interleukin-2 receptor and the non-and hypo-responsivencess to hepatitis B vaccine[J]. Chinese journal of hepatology, 2000, 8(6): 332-334 |
| |
| Authors: | J Xie X Wang G Zhuang H Xu B Hao X Tang Q Wu |
| |
| Affiliation: | Department of Epidemiology Xi'an Medical University, Xi'an 710061, China. |
| |
| Abstract: | OBJECTIVE: To study the relationship between interleukin-2 (IL-2), soluble interleukin-2 receptor (sIL-2R) and the non-and-hypo-responsiveness to hepatitis B vaccine. METHODS: Peripheral blood mononuclear cells (PBMC) isolated from 21 non-and -hypo-responders, 22 hyperresponders and 21 chronic HBsAg carriers were incubated in the presence of HBsAg and phytohaemagglutinin (PHA). The levels of IL-2 and sIL-2R in the supernatants of activated cells were measured by an enzyme-linked immunosorbent assay. RESULTS: The average level of IL-2 in the non-and-hypo-responders was significantly lower than that in the hyperresponders (t=8.80, P<0.001), but was comparable to that in chronic HBsAg carriers (q=0.06, P>0.5). Between the hyperresponders and the non-and-hypo-responders, the average sIL-2R levels showed no noticeable difference. CONCLUSION: The results suggest that low level of IL-2 may be one of the causes and mechanisms of non-and-hypo-responsiveness to hepatitis B vaccine. |
| |
| Keywords: | Hepatitis B vaccine interleukin-2 Souble interleukin-2 receptor |
|
|
