肠道菌群在骨质疏松症发病机制中的研究

骨质疏松症是一种慢性全身性代谢性骨病，由于骨吸收与骨形成的失衡造成骨量减少及骨密度的降低，与此同时骨组织微结构的破坏导致骨折风险升高，影响患者的生活质量甚至威胁生命安全。对于骨质疏松症的发病机制，目前认为与激素、内分泌、免疫、肠道菌群等因素有关。近年来微生物-肠-骨轴成为了骨代谢领域的研究热点。本文将从肠道粘膜屏障、骨免疫学、肠道菌群代谢产物等方面对肠道菌群在骨质疏松症中的发病机制进行综述。

Study on the role of intestinal microflora in the pathogenesis of osteoporosis

osteoporosis is a chronic systemic metabolic bone disease, which results in the decrease of bone mass and bone mineral density due to the imbalance between bone resorption and bone formation. at the same time, the destruction of bone tissue microstructure leads to an increase in the risk of fracture, threatening the quality of life and safety of patients. At present, it is considered that the pathogenesis of osteoporosis is related to hormone, endocrine, immunity, intestinal flora and other factors. In recent years, The microbiota-gut-bone axis has become a research hotspot in the field of bone metabolism. This review will describe the pathogenesis of intestinal flora in osteoporosis from the aspects of intestinal mucosal barrier, bone immunology, metabolites of intestinal flora and so on.