注射用丹参多酚酸治疗缺血性脑卒中的作用机制及临床研究进展

注射用丹参多酚酸（SAFI）是以丹参为原药材,采用现代工艺制备而成的中药注射剂,其主要成分为水溶性酚酸类成分,临床上主要用于轻中度脑卒中的治疗。近年来围绕SAFI治疗缺血性脑卒中开展了大量的药理和临床研究,主要通过对SAFI改善脑部循环、神经保护和抗血栓3个方面的药理机制和临床研究进行总结归纳,以期为后续的作用机制研究指明方向,同时为临床合理用药提供依据。

Research progress on pharmacological mechanism and clinical efficacy of Salvianolic Acid for Injection in treatment of ischemic stroke

Salvianolic Acids for Injection (SAFI) are traditional Chinese medicine injections prepared from Salvia miltiorrhiza by modern technology. The main components of SAFI are water-soluble phenolic acids, which are mainly used in the treatment of mild and moderate cerebral infarction. In recent years, a large number of pharmacological effects and clinical studies have been carried out around SAFI in treatment of ischemic stroke. The clinical and pharmacological studies on the improvement of brain circulation, neuroprotection and antithrombotic effects of SAFI were mainly summarized in this paper, so as to point out the direction for the subsequent research on the mechanism of action of this product and provide foundation for clinical rational application.