基于VOSviewer和CiteSpace的菟丝子知识图谱可视化分析

目的 通过CiteSpace和VOSviewer文献计量学方法，分析菟丝子Cuscutae Semen的研究现状和研究趋势。方法 分别从中国知网数据库与Web of Science数据库核心集中，导出主题为菟丝子的中英文文献，并使用CiteSpace、VOSviewer、Excel软件分别对中英文文献的发文量、作者、发文机构、文献被引频次、关键词等进行分析。结果 共纳入文献485篇，其中中文文献440篇，英文文献45篇。菟丝子的年发文量总体呈现增长趋势。发文量最多的中英文发文机构分别为北京中医药大学（43篇）和Tehran University of Medical Sciences（徳黑兰医科大学，4篇）。研究菟丝子的国家以中国为主。收录文献最多的中英文期刊分别是《时珍国医国药》和Journal of Ethnopharmacology。被引频次前10的中英文文献主要研究方向为菟丝子黄酮对生殖系统的药理作用，以及其抗衰老、抗骨质疏松、抗氧化等药理作用。资助最多的基金均为中国国家自然科学基金。结论 菟丝子的数据挖掘、组方规律的探究，以及菟丝子治疗不孕症等生殖、内分泌系统疾病及抗氧化、抗细胞凋亡等作用机制研究为目前的研究热点。对菟丝子治疗生殖、内分泌系统疾病及抗氧化作用的深入研究为未来的重点研究趋势。

Visual analysis of knowledge mapping of Cuscutae Semen based on VOSviewer and CiteSpace

Objective The research status and trend of Tusizi (Cuscutae Semen) were analyzed by the bibliometric methods of CiteSpace and VOSviewer. Methods The Chinese and English literatures with the topic of Cuscutae Semen were extracted from CNKI database and Web of Science Core Collection database, respectively. CiteSpace, VOSviewer and Excel software were used to analyze the number of published articles, authors, institutions, citation frequency, keywords and so on. Results A total of 485 articles were included, including 440 in Chinese and 45 in English. The annual number of publications of Cuscutae Semen showed an increasing trend. Beijing University of Chinese Medicine (43 papers) and Tehran University of Medical Sciences (4 papers) ranked the top in terms of the number of articles published in both Chinese and English. China is the main country to study Cuscutae Semen. The Chinese and English journals with the most literature included were Lishizhen Medicine and Materia Medica Research and Journal of Ethnopharmacology, respectively. Top 10 most cited Chinese and English literatures mainly focused on the pharmacological effects of flavonoids on the reproductive system and the anti-aging, anti-osteoporosis, anti-oxidation and other pharmacological effects of Cuscutae Semen. The National Natural Science Foundation of China is the largest funding fund. Conclusions Data mining of Cuscutae Semen, study of the rule of the formula, and Cuscutae Semen in treatment of infertility and other reproductive endocrine system diseases, anti-oxidant stress, anti-apoptosis and other mechanisms of action are current hot spots of Cuscutae Semen research. The further trend on pharmacological mechanism effect of Cuscutae Semen in the treatment of reproductive and endocrine system diseases and antioxidation will be the key research trend in the future.