基于CiteSpace探讨马钱子碱的研究现状及趋势分析

目的 对马钱子碱相关的中英文文献进行文献计量分析,探讨马钱子碱的研究现状、研究热点及发展趋势。方法 系统检索中国知网、Web of Science数据库关于马钱子碱的相关文献,基于CiteSpace 5.8.R3软件运用文献计量学方法对发表年份、核心作者、国家、关键词等进行可视化分析。结果 本研究共纳入中文文献439篇、英文文献602篇。近40年马钱子碱相关发文量总体呈稳步增长趋势。中文文献高产作者主要为蔡宝昌研究团队,该团队研究内容涉及马钱子主要生物碱及相应氮氧化物的含量测定、抗肿瘤作用、药动学、炮制转化、新剂型开发等。基于国别分析,中国发文量最高,有待与其他国家进一步发展合作研究。关键词分析表明,中英文文献共同的研究热点主要为2个方面:抗肿瘤等药理活性和机制研究和马钱子碱新型给药系统研究。中文文献研究热点已从质量控制向药理活性及新剂型转变;英文文献多集中于药理活性、新剂型研发领域。结论 马钱子碱研究仍处于发展阶段,研究团队间的合作交流有待加强。减毒增效仍将是未来的研究重点及趋势。

Research Status and Trend Analysis on Brucine Based on CiteSpace

OBJECTIVE To explore the research status, research hotspot and development trend of brucine by carried out the bibliometric analysis of the domestic and foreign literatures related to brucine. METHODS Literature related to brucine in CNKI and Web of Science database was systematically searched, and literature metrology method was applied based on CiteSpace 5.8.R3 software for visual analysis of publication year, core authors, countries, keywords, etc. RESULTS A total of 439 Chinese and 602 English literatures were included in this study. In the past 40 years, the number of publications related to brucine had shown a steady growth trend. The domestic high-yield authors were mainly members of Cai Baochang''s research team. The research content of this team involved the content determination, anti-tumor effect, pharmacokinetics, processing and transformation, and development of new dosage forms of main alkaloids and corresponding nitrogen oxides components in Strychni Semen, etc. Based on country-by-country analysis, China had the highest number of publications, and further research cooperation with other countries was to be developed. Keyword analysis showed that the common research hotspots at home and abroad were mainly in two aspects:anti-tumor pharmacological activity and mechanism research, research on new drug delivery system of brucine. The research on brucine was still in the development stage, and the Chinese literatures had changed from quality control to pharmacological activity and new dosage forms; English literatures mostly focus on the fields of pharmacological activity, new dosage forms and asymmetric synthesis. CONCLUSION The research of brucine is still in the development stage, and the cooperation and communication between research teams need to be strengthened. Toxic reduction and efficiency enhancement will remain the focus and trend of future research.