Cadmium chloride induces contractions of the rat isolated urinary bladder by activation of capsaicin-sensitive sensory nerves |
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| Authors: | R Patacchini P Santicioli S Giuliani C A Maggi A Meli |
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| Institution: | Pharmacology Department, A. Menarini Pharmaceuticals, Florence, Italy. |
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| Abstract: | Cadmium chloride (CdCl2)(30 microM-1 mM) produced a concentration-related contraction of the rat isolated urinary bladder which was abolished by tetrodotoxin (1 microM) or extrinsic bladder denervation (72 h before). Complete cross-desensitization was observed between the contractile response to Cd and capsaicin, indicating that, at the peripheral level, this inorganic calcium channel blocker can activate the 'efferent' function of capsaicin-sensitive sensory nerves. |
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