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目的通过观察分析中重度牙周炎患者血清中对氧磷酶-1（PON1）活性及白细胞介素-6（IL-6）在牙周基础治疗前后的变化，探讨PON1和IL-6与牙周病之间的相关性以及两者在牙周病病情变化中的作用。方法2012年5月至2013年2月在辽宁省人民医院体检中心体检的牙周健康人群30名（牙周健康组）及口腔科就诊的中重度牙周炎患者39例（牙周炎组），对所有受试者进行基础治疗，检查治疗前后PON1、IL-6以及临床牙周检查指标。结果牙周健康组与牙周炎组在基础治疗前比较：牙周炎症指标出血指数（BI）、牙周探诊深度（PD）]及血清IL-6差异均有统计学意义（P〈0．05），血清中PON1活性差异无统计学意义（P〈0．05）。牙周健康组在牙周基础治疗前后各项指标差异均无统计学意义（P〉0．05）。牙周炎组在牙周基础治疗前后比较：牙周炎症指标BI、PD、血清PON1及IL-6与治疗前比较差异均有统计学意义（均P〈0．05）。结论牙周健康人群和中重度牙周炎患者血清PON1活性无差异；牙周基础治疗可改善中重度牙周病患者牙周健康状况，提高血清中PON1活性，降低IL-6水平；中重度牙周炎患者在牙周基础治疗前后血清中PON1活性和IL-6水平的变化存在负相关性。

The relationship between the serum level of PON-1, IL-6 and periodontal diseases

Objective By analysis of serum interleutin-6（IL-6）level and serum paraoxonase-1 （PON1）activity in advanced periodontitis, to explore the possible associations between periodontitis and content of IL-6 level and PON1 activity in serum, and detect their possible effect on the processes of periodontitis. Methods Thirty healthy volunteers and 39 patients who were diagnosed with advanced periodontitis were enrolled in the study. Results The periodontal clinical parameters （BI, PD）and serum IL-6 level in periodontal health group and periodontitis group before treatment had statistically significant difference （P 〈 0.05 ）, but there were no significant differences in serum PON 1 activity in the two groups. There were no significant differences in all the parameters measured before and after treatment in the periodontal healthy group. The changes of the parameters in the advanced periodontitis group before and after treatment had statistical difference. The periodontal clinical parameters （BI, PD）, serum IL-6 level and PON 1 activity had statistically significant difference （P 〈 0.05）. Conclusion The PON 1 activity in patients with advanced periodontitis shows no significant difference from those in the periodontal healthy group （P 〉 0.05）. The periodontal foundation treatment is helpful in improving periodontal status and increasing the serum PON1 activity while decreasing the serum IL-6 level in patients with advanced periodontitis. The difference of the IL-6 level in serum is negatively associated with the PON 1 activity changes in serum before and after the basic periodontal therapy.