首页 | 本学科首页   官方微博 | 高级检索  
     


Prevalence and risk factors of bone metastasis and skeletal related events in patients with primary breast cancer in Japan
Authors:Hiroyasu Yamashiro  Masahiro Takada  Eiji Nakatani  Shiro Imai  Akira Yamauchi  Shigeru Tsuyuki  Yasuo Matsutani  Shingo Sakata  Yasuo Wada  Ryuji Okamura  Tomika Harada  Fumie Tanaka  Yoshio Moriguchi  Hironori Kato  Shunichi Higashide  Norimichi Kan  Hiroshi Yoshibayashi  Hirofumi Suwa  Takashi Okino  Ichiro Nakayama  You Ichinose  Kazuhiko Yamagami  Takashi Hashimoto  Takashi Inamoto  Masakazu Toi
Affiliation:1. Department of Breast Surgery, Kure Medical Center/Chugoku Cancer Center, Kure, Hiroshima, 737-0023, Japan
2. Department of Surgery (Breast Surgery), Kyoto University Hospital, Kyoto, Kyoto, 606-8507, Japan
3. Translational Research Informatics Center, Foundation for Biomedical Research and Innovation, Kobe, Hyogo, 650-0047, Japan
4. Department of Surgery, Kurashiki Central Hospital, Kurashiki, Okayama, 710-8602, Japan
5. Department of Breast Surgery, Kitano Hospital (The Tazuke Kofukai Medical Research Institute), Osaka, Osaka, 530-8480, Japan
6. Department of Breast and General Surgery, Japanese Red Cross Osaka Hospital, Osaka, Osaka, 543-8555, Japan
7. Department of Breast Surgery, Tenri Hospital, Tenri, Nara, 632-8552, Japan
8. Department of Surgery, National Hospital Organization Kyoto Medical Center, Kyoto, Kyoto, 612-8555, Japan
9. Department of Surgery, National Hospital Organization Himeji Medical Center, Himeji, Hyogo, 670-8520, Japan
10. Department of Surgery, Yamatotakada Municipal Hospital, Yamatotakada, Nara, 635-8501, Japan
11. Department of Surgery, Osaka Saiseikai Noe Hospital, Osaka, Osaka, 536-0002, Japan
12. Department of Surgery, Japanese Red Cross Fukui Hospital, Fukui, Fukui, 918-8501, Japan
13. Department of Breast Surgery, Kyoto City Hospital, Kyoto, Kyoto, 604-8845, Japan
14. Breast Surgery, Kobe City Medical Center General Hospital, Kobe, Hyogo, 650-0047, Japan
15. Department of Surgery, Nagahama City Hospital, Nagahama, Shiga, 526-8580, Japan
16. Kan Norimichi Clinic, Kyoto, Kyoto, 606-0836, Japan
17. Department of Surgery, Japanese Red Cross Society Wakayama Medical Center, Wakayama, Wakayama, 640-8558, Japan
18. Department of Breast Surgery, Hyogo Prefectural Tsukaguchi Hospital, Amagasaki, Hyogo, 661-0012, Japan
19. Department of Surgery, Kouga Public Hospital, Kouga, Shiga, 528-0014, Japan
20. Kyoto Min-iren Chuo Hospital, Kyoto, Kyoto, 604-8453, Japan
21. Department of Surgery (Breast Surgery), Takatsuki Red Cross Hospital, Takatsuki, Osaka, 569-1096, Japan
22. Department of Surgery (Breast Surgery), Shinko Hospital, Kobe, Hyogo, 651-0072, Japan
23. Hashimoto Clinic, Kobe, Hyogo, 658-0051, Japan
Abstract:

Background

Bone metastasis (BM) is important for studying systemic spread of breast cancer. It often causes skeletal-related events (SREs) that worsen quality of life. We investigated the prevalence and risk factors for BM and SRE using a dataset from the Breast Oncology Research Network (BORN) in Japan.

Patients and methods

We collected data on primary breast cancer patients with node-positive or node-negative disease at intermediate to high risk of recurrence. The risk factors affecting the BM-free rate, SRE-free rate and overall survival were analyzed by using the Cox proportional hazard model.

Results

Data of 1,779 patients who were diagnosed with breast cancer during 2003–2005 were collected from the BORN and 1,708 cases were used for analysis. The median follow-up duration was 5.71 years. BM developed in 193 cases (11.3 %) and the BM-free rate at 5 years was 89.2 %. The annual hazard ratio of BM development differs remarkably according to the tumor subtype. SREs occurred in 133 (68.9 %) out of 193 patients and the SRE-free rate at 5 years was 92.6 %. In the multivariate analysis, clinical stage (P < 0.0001), number of lymph node (LN) metastases (P = 0.0029), tumor subtype (P = 0.034) and progesterone receptor status (P = 0.038) were independently significant risk factors for BM-free rate, but only clinical stage (P < 0.0001) and number of LN metastases (P = 0.0004) significantly correlated with SRE-free rate.

Conclusions

This retrospective study clarifies the prevalence and risk factors for BM and SRE in Japanese breast cancer patients. Our results show the importance of considering subtype in the care of BM and SRE.
Keywords:
本文献已被 SpringerLink 等数据库收录！
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号