| 抗肿瘤新药研究的新型模式生物斑马鱼 |
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| 引用本文： | 牛荣丽,阎松,杜长青,林秀坤. 抗肿瘤新药研究的新型模式生物斑马鱼[J]. 中国新药杂志, 2006, 15(7): 496-500 |
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| 作者姓名： | 牛荣丽 阎松 杜长青 林秀坤 |
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| 作者单位： | 中国科学院海洋研究所,青岛,266071 |
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| 摘 要： | 斑马鱼（Danio rerio），是一种用于研究脊椎动物胚胎学和发育遗传学的模式生物。近年来，利用斑马鱼来建立人类疾病研究模型已成为新的研究亮点。笔者就斑马鱼作为一种抗肿瘤新药研究模式生物所具有的优势、应用研究及其前景做一综述。
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| 关 键 词： | 斑马鱼 筛选 肿瘤模型 |
| 文章编号： | 1003-3734（2006）07-0496-05 |
| 收稿时间： | 2005-10-08 |
| 修稿时间： | 2005-10-08 |
Zebrafish: a new model for anti-cancer agents |
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| NIU Rong-li,YAN Song,DU Chang-qing,LIN Xiu-kun. Zebrafish: a new model for anti-cancer agents[J]. Chinese Journal of New Drugs, 2006, 15(7): 496-500 |
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| Authors: | NIU Rong-li YAN Song DU Chang-qing LIN Xiu-kun |
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| Affiliation: | Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China |
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| Abstract: | Zebrafish (Danio rerio) embryo is one of the most versatile models for studying vertebrate biology. Among the model systems for drug development, the zebrafish model has become prized because of its fecundity, its morphological and physiological similarity to mammals, the existence of many genomic tools and the ease with which large phenotype-based screens can be performed. This paper reviewed the unique characteristics of the use of the zebrafish as a new model for assessing anti-tumor agent candidates, and its future attributions in drug development process. |
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| Keywords: | zebrafish sreen cancer model |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
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