| P27基因在口腔癌组织中的表达及其意义 |
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| 引用本文： | 吴民献,方林彬.P27基因在口腔癌组织中的表达及其意义[J].职业与健康,2008,24(10):925-926. |
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| 作者姓名： | 吴民献 方林彬 |
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| 作者单位： | 1. 广东省湛江市第二中医医院,524013
2. 广东医学院附属医院 |
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| 摘 要： | 目的探讨肿瘤抑制基因p27在口腔癌组织中的表达及其临床意义。方法应用免疫组织化学方法（SP法）检测p27基因在62例口腔癌组织和20例正常口腔黏膜组织中的表达。结果62例口腔癌组织中，p27的阳性表达率为38．7（24／62）；p27的阳性表达与口腔病灶大小、临床分期、细胞分化程度、转移及预后有密切关系（P〈0．01或P〈0．05）；与患者年龄无关（P〉0．05）。结论p27基因的表达与口腔癌的生长、浸润及淋巴结转移有关，其表达水平的高低可作为判断口腔癌预后的重要指标之一。
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| 关 键 词： | 抑癌基因 P27基因 预后 口腔肿瘤 |
| 文章编号： | 1004-1257(2008)10-0925-02 |
| 修稿时间： | 2007年7月10日 |
Expression of p27 Genes in Oral Carcinoma Tissues and Its Clinical Significance |
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| WU Min-xian,FANG Lin-bin.Expression of p27 Genes in Oral Carcinoma Tissues and Its Clinical Significance[J].Occupation and Health,2008,24(10):925-926. |
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| Authors: | WU Min-xian FANG Lin-bin |
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| Institution: | WU Min-xian, FANG Lin-bin ( Zhanjiang Second Hospital of Chinese Medicine, Guangdong, 524013, China } |
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| Abstract: | Objective] To explore the expression of p27 genes in oral carcinoma tissues and its clinical significance. Methods] SP method was applied to detect the expression of p27 genes in the tissues of 62 cases of oral carcinoma and 20 healthy people. Re- suits]The positive rate of p27 expression in oral carcinoma tissues was 38.7% （24/62）, which was closely related with the carci- noma size, clinical stage, lymphnode metastasis and prognosis （ P 〈 0.01 or P 〈 0.05 ）, but had no relationship with the patients′ age （ P 〉0.05 ）. Conclusion]The expression of p27 genes is correlated with the growth and soakage of oral carcinoma and lymph- node metastasis, the expression level can be applied as an important index for the judgment of oral carcinoma prognosis. |
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| Keywords: | Tumor suppressor gene p27 genes Prognosis Oral carcinoma |
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