Evaluation of urinary metal concentrations and sperm DNA damage in infertile men from an infertility clinic |
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| Affiliation: | 1. State Key Joint Laboratory of Environment Simulation and Pollution Control, School of Environment, Tsinghua University, Beijing 100084, China;2. State Environmental Protection Key Laboratory of Sources and Control of Air Pollution Complex, Beijing 100084, China;3. College of Electromechanical Engineering, Qingdao University of Science and Technology, Qingdao 266061, China;1. Department of Biomedical Sciences, School of Biosciences and Technology, VIT, Vellore, Tamil Nadu 632014, India;2. Department of Applied Physiology, Faculty of Medicine, University of Miyazaki, Miyazaki 889 1692, Japan;3. Regional Medical Research Center, NE (Indian Council of Medical Research), Dibrugarh 786001, Assam, India |
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| Abstract: | This study aimed to examine associations between urinary metal concentrations and sperm DNA damage. Thirteen metals [arsenic (As), cadmium (Cd), cobalt (Co), chromium (Cr), copper (Cu), iron (Fe), lead (Pb), manganese (Mn), molybdenum (Mo), mercury (Hg), nickel (Ni), selenium (Se), and zinc (Zn)] were detected in urine samples of 207 infertile men from an infertility clinic using inductively coupled plasma mass spectrometry, and also, sperm DNA damage (tail length, percent DNA tail, and tail distributed moment) were assessed using neutral comet assay. We found that urinary Hg and Ni were associated with increasing trends for tail length (both p for trend < 0.05), and that urinary Mn was associated with increasing trend for tail distributed moment (p for trend = 0.02). These associations did persist even when considering multiple metals. Our results suggest that environmental exposure to Hg, Mn, and Ni may be associated with increased sperm DNA damage. |
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| Keywords: | Comet assay Male infertility Male reproductive health Metals Sperm DNA damage |
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