Partitioning and kinetics of methylmercury among organs in captive mink (Neovison vison): A stable isotope tracer study |
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| Affiliation: | 1. University of Gdansk, Faculty of Oceanography and Geography, Division of Marine Chemistry and Environmental Protection, Al. Piłsudskiego 46, 81-378 Gdynia, Poland;2. University of Gdansk, Faculty of Oceanography and Geography, Division of Marine Geology, Al. Piłsudskiego 46, 81-378 Gdynia, Poland;3. Institute of Oceanology, Polish Academy of Sciences, Marine Chemistry and Biochemistry Department, Powstańców Warszawy 55, 81-712 Sopot, Poland;4. Leibniz Institute for Baltic Sea Research, Department of Biological Oceanography, Seestr. 15, 18119 Rostock, Germany;1. Memorial University of Newfoundland, St. John''s, Newfoundland A1B 3X9, Canada;2. Great Lakes Institute of Environmental Research, University of Windsor, 401 Sunset Avenue, Windsor, Ontario N9B 3P4, Canada;3. Environment Canada, Canada Centre for Inland Waters, 867 Lakeshore Road, Burlington, Ontario L7R 4A6, Canada;4. Fisheries and Oceans Canada, 501 University Crescent, Winnipeg, Manitoba R3T 2N6, Canada;5. University of Manitoba, 500 University Crescent, Winnipeg, Manitoba R3T 2N2, Canada;6. Environmental Sciences Group, Royal Military College of Canada, PO Box 17000, Stn Forces, Kingston, Ontario K7K 7B4, Canada;1. University of Gdansk, Faculty of Oceanography and Geography, Institute of Oceanography, Department of Marine Chemistry and Environmental Protection, Al. Marszałka Piłsudskiego 46, 81-378 Gdynia, Poland;2. University of Gdansk, Faculty of Oceanography and Geography, Institute of Oceanography, Professor Krzysztof Skóra Hel Marine Station, ul. Morska 2, 84-150 Hel, Poland |
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| Abstract: | Despite the importance of methylmercury (MeHg) as a neurotoxin, we have relatively few good data on partitioning and kinetics of MeHg among organs, particularly across the blood–brain barrier, for mammals that consume large quantities of fish. The objective of this study was to determine the partition coefficients between blood and brain, liver and kidney and fur for MeHg under steady-state conditions and to measure the half-lives for MeHg in these organs. Captive mink (Neovison vison) were fed a diet enriched with two stable isotopes of Hg, Me199Hg and Me201Hg for a period of 60 days. After a period of 10 days the diet was changed to contain only Me201Hg so that, between days 10 and 60, we were able to measure both uptake and elimination rates from blood, brain, liver kidney and fur. Liver and kidney response was very rapid, closely following changes in blood concentrations but there was a small lag time between peak blood concentrations and peak brain concentrations. Half-lives for MeHg were 15.4, 10.2 and 13.4 days for brain, liver and kidney, respectively. There was no measurable conversion of the MeHg to inorganic Hg (IHg) in the brain over the 60 day period, unlike in liver and kidney. |
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| Keywords: | Mercury Stable isotopes Kinetics Distribution Mink |
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