Oxidative stress mediates dibutyl phthalateinduced anxiety-like behavior in Kunming mice |
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| Affiliation: | 1. College of Basic Medical Science, Hubei University of Science and Technology, Xianning 437100, China;2. Laboratory of Environmental Biomedicine, School of Life Sciences, Central China Normal University, Wuhan 430079, China;1. Departamento de Química Analítica, Facultad de Químicas, Complutense University of Madrid, Avenida Complutense s/n, 28040 Madrid, Spain;2. Laboratoire de Chimie Analytique Bio-Inorganique et Environnement, UMR 5254 CNRS - Université de Pau et des Pays de l''Adour, Pau, France;1. Department of Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran;2. Metabolic Disorders Research Center, Endocrinology and Metabolism Molecular—Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran;3. Department of Biochemistry, Faculty of Medicine, Iran University of Medical Sciences, 1449614535 Tehran, Iran;4. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, Iran;5. H. Aliasghar Children’s Hospital, Iran University of Medical Sciences, Tehran, Iran;1. College of Pharmacy, Pusan National University, Busan, 46241, Republic of Korea;2. Molecular Regulation of Aging, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan |
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| Abstract: | Among all phthalate esters, dibutyl phthalate (DBP) is only second to di-(2-ethylhexyl) phthalate (DEHP) in terms of adverse health outcomes, and its potential cerebral neurotoxicity has raised concern in recent years. DBP exposure has been reported to be responsible for neurobehavioral effects and related neurological diseases. In this study, we found that neurobehavioral changes induced by DBP may be mediated by oxidative damage in the mouse brain, and that the co-administration of Mangiferin (MAG, 50 mg/kg/day) may protect the brain against oxidative damage caused by DBP exposure. The results of ethological analysis (elevated plus maze test and open-field test), histopathological examination of the brain, and assessments of oxidative stress (OS) in the mouse brain showed that there is a link between oxidative stress and anxiety-like behavior produced by DBP at higher doses (25 or 125 mg/kg/day). Biomarkers of oxidative stress encompass reactive oxygen species (ROS), glutathione (GSH), malondialdehyde (MDA) and DPC coefficients (DPC). MAG (50 mg/kg/day),administered as an antioxidant,can attenuatetheanxiety-like behavior of the tested mice. |
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| Keywords: | Dibutyl phthalate (DBP) Anxiety-like behavior Oxidative stress (OS) Mangiferin (MAG) Mice |
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