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Histopathology-validated machine learning radiographic biomarker for noninvasive discrimination between true progression and pseudo-progression in glioblastoma |
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| Authors: | Hamed Akbari MD PhD Saima Rathore PhD Spyridon Bakas PhD MacLean P. Nasrallah MD PhD Gaurav Shukla MD PhD Elizabeth Mamourian Martin Rozycki MSc Stephen J. Bagley MD MSCE Jeffrey D. Rudie MD PhD Adam E. Flanders MD Adam P. Dicker MD PhD Arati S. Desai MD Donald M. O’Rourke MD Steven Brem MD Robert Lustig MD Suyash Mohan MD Ronald L. Wolf MD PhD Michel Bilello MD PhD Maria Martinez-Lage MD Christos Davatzikos PhD |
| Affiliation: | 1. Center for Biomedical Image Computing and Analytics, University of Pennsylvania, Philadelphia, Pennsylvania;2. Center for Biomedical Image Computing and Analytics, University of Pennsylvania, Philadelphia, Pennsylvania Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania;3. Center for Biomedical Image Computing and Analytics, University of Pennsylvania, Philadelphia, Pennsylvania Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania;4. Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania;5. Center for Biomedical Image Computing and Analytics, University of Pennsylvania, Philadelphia, Pennsylvania Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania Helen F. Graham Cancer Center and Research Institute, ChristianaCare, Newark, Delaware;6. Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania;7. Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania;8. Department of Radiology, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania;9. Department of Radiation Oncology, Sidney Kimmel Medical College and Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania;10. Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania;11. Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania;12. Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts |
| Abstract: | |
| Keywords: | glioblastoma machine learning pseudo-progression radiographic biomarker true progression |