The Development of Foveolar-type Gastric Adenocarcinoma during Maintenance Therapy of Vonoprazan for Reflux Esophagitis |
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| Authors: | Masahiro Saito Tomoyuki Koike Yasuaki Abe Kenichiro Nakagawa Takeshi Kanno Xiaoyi Jin Waku Hatta Kaname Uno Naoki Asano Akira Imatani Fumiyoshi Fujishima Atsushi Masamune |
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| Affiliation: | 1.Division of Gastroenterology, Tohoku University Graduate School of Medicine, Japan; 2.Tohoku University Tohoku Medical Megabank Organization, Japan; 3.Division of Pathology, Tohoku University Graduate School of Medicine, Japan |
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| Abstract: | We herein report the first case of foveolar-type gastric adenocarcinoma that developed after the initiation of vonoprazan (VPZ). A 51-year-old man had heartburn at the first visit and reflux esophagitis endoscopically, so he started taking VPZ. An approximately 5-mm-sized reddish polyp with a raspberry-like morphology was detected at the anterior wall of the upper body of the stomach 156 weeks after starting maintenance therapy with VPZ 10 mg/day. It was diagnosed as foveolar-type gastric adenocarcinoma based on a biopsy. Another approximately 4-mm-sized foveolar-type gastric adenocarcinoma was also detected at the posterior wall of the middle body of the stomach. |
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| Keywords: | potassium-competitive acid blocker (P-CAB) vonoprazan (VPZ) foveolar-type gastric adenocarcinoma serum gastrin |
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