Evaluation of a pre-surgical functional MRI workflow: From data acquisition to reporting |
| |
Institution: | 1. Brain Research Imaging Centre, The University of Edinburgh, UK;2. Centre for Clinical Brain Sciences, The University of Edinburgh, UK;3. Department of Psychology, Stanford University, Stanford, USA;4. Division of Clinical Neuroscience, NHS-Lothian, Edinburgh, UK;5. School of Informatics, The University of Edinburgh, UK;1. Department of Neurosurgery, Montpellier University Medical Center, Montpellier 34295, France;2. Institute for Neuroscience of Montpellier, INSERM U-1051, Hôpital Saint Eloi, Montpellier 34298, France;1. UMR 1129, INSERM, Paris Descartes University, CEA-Saclay, Gif sur Yvette, France;2. UNIACT/Neurospin, I2BM, DSV, CEA-Saclay, Gif sur Yvette, France |
| |
Abstract: | PurposePresent and assess clinical protocols and associated automated workflow for pre-surgical functional magnetic resonance imaging in brain tumor patients.MethodsProtocols were validated using a single-subject reliability approach based on 10 healthy control subjects. Results from the automated workflow were evaluated in 9 patients with brain tumors, comparing fMRI results to direct electrical stimulation (DES) of the cortex.ResultsUsing a new approach to compute single-subject fMRI reliability in controls, we show that not all tasks are suitable in the clinical context, even if they show meaningful results at the group level. Comparison of the fMRI results from patients to DES showed good correspondence between techniques (odds ratio 36).ConclusionProviding that validated and reliable fMRI protocols are used, fMRI can accurately delineate eloquent areas, thus providing an aid to medical decision regarding brain tumor surgery. |
| |
Keywords: | Protocol Workflow Functional MRI Surgical planning Brain tumors |
本文献已被 ScienceDirect 等数据库收录! |
|