Ligustrazine attenuates inflammation and the associated chemokines and receptors in ovalbumine-induced mouse asthma model |
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| Institution: | 1. Department of Integrative Medicine, Huashan Hospital, Fudan University, China;2. The Academy of Integrative Medicine, Fudan University, China;1. Jiangxi Medical School, Nanchang University, Nanchang 330006, China;2. Jiangxi Academy of Medical Sciences, Nanchang University, Nanchang 330006, China;3. Jiangxi Provincial Key Laboratory of Basic Pharmacology, Nanchang University School of Pharmaceutical Science, Nanchang 330006, China;4. Jiangxi Provincial Key Laboratory of Molecular Medicine, the Second Affiliated Hospital, Nanchang University, Nanchang 330006, China;1. MOE Key Laboratory of Bioinformatics and Bioinformatics Division, TNLIST/Department of Automation, Tsinghua University, Beijing, 100084, China;2. Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, 100700, China;3. Institute for Advancing Translational Medicine in Bone & Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong Special Administrative Region, 00852, China;4. China-Japan Friendship Hospital, Beijing, 100030, China;5. Tianjin International Joint Academy of Biotechnology & Medicine, Tianjin, 300457, China |
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| Abstract: | Ligustrazine which is isolated from Chinese herb ligusticum chuanxiong hort, has been widely used in traditional Chinese medicine (TCM) for asthma treatment. In this study, we aim to observe the effect of ligustrazine on inflammation and the associated chemokines and receptors in ovalbumin (OVA)-induced mouse asthma model. Our data demonstrates that ligustrazine suppresses airway hyperresponsiveness to methacholine and lung inflammation in OVA-induced mouse asthma model. Ligustrazine also induces inhibition of inflammatory cells including neutrophils, lymphocytes and eosinophils. In addition, ligustrazine significantly reduces IL-4, IL-5, IL-17A, CCL3, CCL19 and CCL21 level in BALF of asthma mice. Furthermore, ligustrazine induces down-regulation of CCL19 receptor CCR7, STAT3 and p38 MAPK protein expression. Collectively, these results suggest that ligustrazine is effective in attenuation of allergic airway inflammatory changes and related chemokines and receptors in OVA-induced asthma model, and this action might be associated with inhibition of STAT3 and p38 MAPK pathway, which indicates that ligustrazine may be used as a potential therapeutic method to treat asthma. |
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| Keywords: | Airway inflammation Asthma Chemokines Ligustrazine STAT3 p38 MAPK |
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