Glutathione,glutathione-related enzymes,and oxidative stress in individuals with subacute occupational exposure to lead |
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| Affiliation: | 1. Department of Health Risk Management, College of Public Health, China Medical University, Taichung, Taiwan;2. Department of Medical Research, China Medical University and Hospital, Taichung, Taiwan;3. Department of Urology, China Medical University and Hospital, Taichung, Taiwan;4. Department of Medicine, College of Medicine, China Medical University and Hospital, Taichung, Taiwan;5. Division of Environmental Health and Occupational Medicine, National Health Research Institutes, Zhunan, Miaoli County, Taiwan;6. Department of Family Medicine, China Medical University and Hospital, Taichung, Taiwan;7. Department of Chemistry, Fu Jen Catholic University, New Taipei City, Taiwan |
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| Abstract: | The aim of the study was to investigate the influence of subacute exposure to lead on the glutathione-related antioxidant defense and oxidative stress parameters in 36 males occupationally exposed to lead for 40 ± 3.2 days.Blood lead level in the examined population increased significantly by 359% due to lead exposure. Simultaneously, erythrocyte glutathione level decreased by 16%, whereas the activity of glutathione-6-phosphate dehydrogenase in erythrocytes and leukocytes decreased by 28% and 10%, respectively. Similarly, the activity of glutathione-S-transferase in erythrocytes decreased by 45%. However, the activity of glutathione reductase in erythrocytes and leukocytes increased by 26% and 6%, respectively, whereas the total oxidant status value in leukocytes increased by 37%.Subacute exposure to lead results in glutathione pool depletion and accumulation of lipid peroxidation products; however, it does not cause DNA damage. Besides, subacute exposure to lead modifies the activity of glutathione-related enzymes. |
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| Keywords: | Subacute exposure to lead Glutathione Oxidative stress DNA damage Lipid peroxidation |
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