Nb-benzoyltryptamine derivatives with relaxant activity in guinea-pig ileum |
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| Authors: | Gutierrez Stanley Juan C de S Claudino Fladmir Da Silva Bagnólia A Câmara Celso A de Almeida Reinaldo N de Fátima V de Souza Maria Da Silva Marcelo S Da-Cunha Emídio V L Barbosa-Filho José Maria |
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| Affiliation: | 1. Universitäts-Herzzentrum Freiburg • Bad Krozingen, Abteilung für Kardiologie und Angiologie II, Südring 15, D-79189 Bad Krozingen, Germany;2. Department of Psychiatry and Psychotherapy, University of Freiburg Medical School, Hauptstr. 5, D-79014 Freiburg, Germany;3. VivaCell Biotechnology GmbH, Ferdinand-Porsche-Str. 5, D-79211 Denzlingen, Germany;1. Molecular Therapy Department, Institute of Ophthalmology, 11/14 Bath Street, London EC1V 9EL, UK;2. Centre for Translational Medicine and Therapeutics, William Harvey Research Institute, St Barts and the Royal London School of Medicine, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK;3. Centre for Biochemical Pharmacology, William Harvey Research Institute, St Barts and the Royal London School of Medicine, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK |
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| Abstract: | A series of derivatives analogous to Nb-benzoyltryptamine were synthesized by the Schotten-Bauman procedure. The products obtained were: Nb-4-methoxy-benzoyltryptamine, Nb-2,4-dimethoxy-benzoyltryptamine, Nb-3,4-dimethoxy-benzoyltryptamine, Nb-3,4-methylenedioxy-benzoyltryptamine and Nb-3,4,5-trimethoxy-benzoyltryptamine. They were characterized through the usual spectrometric methods (UV, IR, 1H and 13C NMR) and showed non-selective relaxant activity in guinea-pig ileum pre-contracted with acetylcholine, histamine and KCl. |
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