A new tetracycline antibiotic with antitumor activity. II. The structural elucidation of SF2575. |
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| Authors: | M Hatsu T Sasaki S Gomi Y Kodama M Sezaki S Inouye S Kondo |
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| Affiliation: | Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd., Yokohama, Japan. |
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| Abstract: | The structure of a new antitumor antibiotic SF2575, has been determined by spectroscopic analyses of the antibiotic and its alkaline degradation products. The relative stereochemistry has been confirmed by X-ray crystallographic analysis. The antibiotic has a 2-naphthacenecarboxamide carbon skelton which is structurally related to the tetracycline antibiotics and it is unique by bearing C-glycoside, salicyclic acid and angelic acid moieties. |
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