| 高频重复经颅磁刺激对大鼠神经元及血脑屏障超微结构的影响 |
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| 引用本文： | 方征宇,岳翔,黄晓琳. 高频重复经颅磁刺激对大鼠神经元及血脑屏障超微结构的影响[J]. 中国康复, 2010, 25(5): 327-329. DOI: 10.3870/zgkf.2010.05.001 |
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| 作者姓名： | 方征宇 岳翔 黄晓琳 |
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| 作者单位： | 华中科技大学同济医学院附属同济医院康复医学科,武汉,430030 |
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| 基金项目： | 国家自然科学基金资助项目，华中科技大学同济医学院附属同济医院科研基金 |
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| 摘 要： | 目的:研究高频重复经颅磁刺激(rTMS)对大鼠神经元及血脑屏障超微结构的影响。方法:健康成年SD大鼠14只,随机分为对照组和rTMS组各7只,rTMS组以20 Hz、80%最大输出强度行rTMS,鼠脑中线旁左眼后眦与左耳前缘连线的中点接受最强磁刺激,每天1次,15 min。连续2周后取脑,制作超薄切片,在电子显微镜下观察神经元及血脑屏障的超微结构。结果:在刺激过程中,rTMS组未出现肢体强直、阵挛等异常活动。扫描电子显微镜下发现,rTMS组与对照组比较,神经元,核内染色质聚集边集,粗面内质网附着的核糖体数量和线粒体减少,部分线粒体水肿;毛细血管内皮细胞、基膜及周细胞出现明显水肿,部分神经元及毛细血管内皮细胞失去正常形态和结构。结论:长期高频rTMS可一定程度破坏大鼠神经元细胞器及血脑屏障。提示在将高频rTMS应用于大脑时应谨慎。
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| 关 键 词： | 磁刺激 神经元 血脑屏障 大鼠 |
Effects of High-frequency Repetitive Transcranial Magnetic Stimulation on Ultrastructure of Neurons and Blood-brain Barrier in Rats FANG |
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| Fang Zheng-yu,YUE Xiang,HUANG Xiao-lin. Effects of High-frequency Repetitive Transcranial Magnetic Stimulation on Ultrastructure of Neurons and Blood-brain Barrier in Rats FANG[J]. Chinese Journal of Rehabilitation, 2010, 25(5): 327-329. DOI: 10.3870/zgkf.2010.05.001 |
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| Authors: | Fang Zheng-yu YUE Xiang HUANG Xiao-lin |
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| Affiliation: | FANG Zheng-yu,YUE Xiang,HUANG Xiao-lin.Department of Rehabilitation Medicine,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China |
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| Abstract: | Objective: To observe the effects of high-frequency repetitive transcranial magnetic stimulation(rTMS) on ultrastructure of neurons and blood-brain barrier in rats.Methods: Fourteen Sprague Dawley rats were randomly divided into two groups: control group and magnetic stimulation group.The animals in magnetic stimulation group were subjected to 20 Hz rTMS for 15 min per day at the intensity of 80% maximum output of stimulator for 14 days.Left motor cortex was selected as stimulation locus.The brains were rem... |
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| Keywords: | magnetic stimulation neuron blood-brain barrier rats |
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