人参果皂苷注射液对高脂血症大鼠血脂代谢的影响

目的: 观察人参果皂苷注射液（IGFS）对实验性高脂血症大鼠血清总胆固醇（TC）、脂蛋白-胆固醇代谢的影响及其抗氧化作用。方法:大鼠连续腹腔注射IGFS 10、20和40 mg•kg^-1•d^-1 15 d，测血清TC、脂蛋白-胆固醇、过氧化脂质(LPO)及血浆前列环素（PGI₂）、血栓素A₂（TXA₂）含量，血清和肝脏超氧化物歧化酶（SOD）活性及全血和血浆黏度，并观察肝脏脂肪沉积情况。结果:IGFS 20、40 mg•kg^-1•d^-1能明显降低甘油三酯（TG）、TC、低密度脂蛋白-胆固醇（LDL-c）、TXA₂、LPO及全血黏度，并能明显提高实验性高脂血症大鼠PGI₂水平及SOD活性，亦能使TC/HDL-c及LDL-c/HDL-c比值明显降低，PGI₂/TXA₂比值明显升高，病理检查可见肝脏脂肪沉积明显减轻。40 mg•kg^-1•d^-1亦能明显提高HDL-c含量。结论: IGFS可能通过调节体内血脂代谢，提高PGI₂/TXA₂比值，纠正自由基代谢紊乱，发挥抗动脉硬化作用。

Effects of IGFS on blood lipid metabolism in experimental hyperlipidemia rats

Objective To observe the effects of injection of ginseng fruit saponins (IGFS) on total cholesterol(TC), lipoprotein cholesterol metabolism and antioxidative activity in experimental hyperlipidemia rats. Methods The TC, lipoprotein cholesterol and lipidperoxidation(LPO) contents, prostacycline (PGI 2) and thromboxane(TXA 2) levels, superoxidedismutase (SOD) activity and blood viscosity were measured respectively in hyperlipidemia rats which had been given IGFS 10, 20 and 40 mg·kg -1 ·d -1 ip, respectively, for fifteen days. In addition, fat accumulation in liver was observed. Results The triglyceride(TG), TC, low density lipoprotein cholesterol (LDL-c) in serum,TXA 2 in plasma, LPO in serum and liver and blood viscosity were decreased significantly, and PGI 2 in plasma and SOD in serum and liver were significantly increased after administration with IGFS (20 and 40 mg·kg -1 ·d -1 ) in experimental hyperlipidemia rats. Moreover, IGFS decreased ratios of TC/HDL-c and LDL-c/HDL-c, increased the ratio of PGI 2/TXA 2 and inhibit fat accumulation in liver. The content of high density lipoprotein cholesterol (HDL-c) in serum were significantly increased after adminstration IGFS (40 mg·kg -1 ·d -1 ) in experimental hyperlipidemia rats. Conclusion IGFS can inhibit arterioscleros by improving cholesterol and lipoprotein cholesterol metabolism, suppressing LPO and increasing antioxidation.