Characterisation and molecular epidemiology of extended-spectrum β-lactamase-producing Enterobacter cloacae isolated from a district teaching hospital in Taiwan |
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| Authors: | W-L Yu K-C Cheng C-J Chi H-E Chen Y-C Chuang L-T Wu |
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| Institution: | Department of Critical Care Medicine, Chi-Mei Medical Center, Yungkang, Taiwan. |
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| Abstract: | Enterobacter cloacae (n = 110) isolates from a district hospital in Taiwan were screened for extended-spectrum beta-lactamases (ESBLs). In total, 17 ESBL-producers were identified, based on the combination-disk synergy test using cefotaxime and ceftazidime +/- clavulanic acid. Investigation of ESBL genes in 33 ceftazidime-resistant isolates revealed the SHV-12 gene in the same 17 ESBL-producers. In addition, one isolate also carried the CTX-M-3 gene, and two isolates also carried the CTX-M-9 gene. No major epidemic clone of ESBL-producers was identified by pulsed-field gel electrophoresis. Routine screening for the ESBL phenotype, focusing on ceftazidime-resistant E. cloacae, should be undertaken in this area. |
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| Keywords: | CTX-M-3 CTX-M-9 Enterobacter cloacae extended-spectrum β-lactamases SHV-12 |
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