| 尼可地尔对心肌缺血再灌注损害的作用 |
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| 引用本文： | 祝建芳,田莉,朱元州,曹旭.尼可地尔对心肌缺血再灌注损害的作用[J].心血管康复医学杂志,2010,19(2):183-186. |
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| 作者姓名： | 祝建芳 田莉 朱元州 曹旭 |
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| 作者单位： | 1. 华中科技大学同济医学院附属协和医院,湖北,武汉,430022
2. 武汉科技大学附属天佑医院 |
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| 摘 要： | 目的：观察KATP通道开放剂预处理对在体缺血再灌注（ischemia／reperfusion，I／R）心脏的影响。方法：建立在体大鼠心脏缺血再灌注模型。将60只大鼠随机分成4组：缺血再灌注（I／R）组，尼可地尔（NIC）组，KATP通道阻滞剂格列苯脲（GLI）＋NIC组，GLI组。测定各组心肌梗塞范围，血清肌酸激酶（CK），乳酸脱氢酶（LDH）浓度，监测各组心电图，应用透射电镜观察超微结构的变化。结果：与I／R组比较，NIC组心肌梗塞范围显著减小（52．9±14．2）％：（20．3±6．4）％。P〈0．005]，血浆CK，LDH浓度显著减少（P〈0．05），但并不能减少心律失常的发生；GLI＋NIC组和GLI组与I／R组相比，心肌梗塞范围、血清CK、LDH浓度无显著性差异。结论：非特异性KATP通道开放剂尼可地尔有部分心肌保护作用，推测在缺血再灌注中发挥作用的KATP通道可能是对心电生理影响较小的亚型。
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| 关 键 词： | 再灌注损伤 尼可地尔 格列苯脲 |
Effect of nicorandil-KATP channel opener on ischemia reperfusion in myocardium of rat |
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| ZHU Jian-fang,TIAN Li,ZHU Yuan-zhou,CAO Xu.Effect of nicorandil-KATP channel opener on ischemia reperfusion in myocardium of rat[J].Chinese Journal of Cardiovascular Rehabilitation Medicine,2010,19(2):183-186. |
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| Authors: | ZHU Jian-fang TIAN Li ZHU Yuan-zhou CAO Xu |
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| Institution: | ZHU Jian-fang,TIAN Li,ZHU Yuan-zhou,CAO Xu Department of Cardiology,Union Hospital,Tongji Medical College,Huazhong University of Science , Technology,Wuhan,Hubei,430022,China |
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| Abstract: | Objective:To investigate the effect of pretreatment with nicorandil(NTC)-KATP channel opener on ischemiareperfusion(IR) rat in myocardium of rat.Methods:The snare for occlusion and reperfusion had been put into the anterior descending coronary artery in 60 rats,which were divided into four groups: ischemiareperfusion(IR) group,nicorandil(NIC) group,glibenclamide(GLI),KATP channel inhibitor+NIC group,GLI group.The activity of creatine kinase and lactate dehydrogenase in plasma and the infarct size were measu... |
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| Keywords: | Ischemicinjury Nicorandil Glibenclamide Patassium channel |
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