Distribution of 18F-5-fluorouracil in tumor-bearing mice and rats. |
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| Authors: | J Shani W Wolf T Schlesinger H L Atkins P R Bradley-Moore V Casella J S Fowler D Greenberg T Ido R M Lambrecht R MacGregor C Mantescu R Neirinckx P Som A P Wolf I Wodinsky K Meaney |
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| Affiliation: | 1. Department of Nuclear Medicine, University Hospital Würzburg, 97080 Würzburg, Germany;1. Department of Physical Chemistry, Faculty of Sciences, University of Granada, Av. Fuentenueva s/n, 18071, Spain;2. School of Biological Sciences, Queeńs University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, UK;1. Radiopharmaceutical Chemistry Laboratory, Turku PET Centre, University of Turku, Turku, Finland;2. Department of Chemistry, University of Turku, Turku, Finland;3. Accelerator Laboratory, Åbo Akademi University, Turku, Finland;1. Institute for Nuclear Research, Hungarian Academy of Sciences, 4026 Debrecen, Hungary;2. Nishina Center for Accelerator-Based Science, RIKEN, Wako 351-0198, Japan;3. Faculty of Science, Hokkaido University, Sapporo 060-0810, Japan;4. Graduate School of Science, Hokkaido University, Sapporo 060-0810, Japan |
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| Abstract: | Extensive distribution studies of 18F-5-fluorouracil (18F-5-FU) in control and tumor-bearing mice (seven lines) and rats (eight lines) that have been shown or suspected to be responsive; to 5-FU treatment were investigated with 18F-5-FU. Studies were performed as a function of time, loading dose of 5-FU, and after a pretreatment regimen of 5-FU. Following the parenteral administration of 18F-5-FU to tumor-bearing mice and rats there was slight preferential uptake by some of the tumor types, particularly subcutaneous leukemic tumors and breast adenocarcinomas. The degree of concentration in tumor tissue in comparison with surrounding tissues (blood, muscle) was not such as to consider the radiopharmaceutical suitable for tumor localization. However, sufficient amounts of radioactivity localized in some tu,ors so that it might be possible to determine if a correlation exists between tumor uptake and anti-tumor effect of 5-fluorouracil. Another possible area of use might be in regulating the method of administration of the chemotherapeutic agent. |
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