局部应用水蛭素对扩张皮瓣静脉淤血的防治

目的 探讨局部应用水蛭素对扩张皮瓣静脉淤血的防治作用。方法 以白色小型家猪为实验对象,将其模拟成扩张皮肤转移术后的淤血皮瓣,随机分成三组,A组（局部注射天然水蛭素,0.5 U/皮瓣）、B组（局部注射天然水蛭素,1 U/皮瓣）和对照组。进行大体观察、病理切片和ET-1、NO、TXB2的测定。结果 用药组（A组与B组间差异无显著意义）术后与对照组比较淤血消散快。光镜下用药组与对照组微血管淤血同期比较有明显差异。用药组的ET-1、NO、TXB2与对照组同期比较差异有显著意义（P＜0.05）。结论 水蛭素的局部应用对扩张皮瓣静脉淤血有明显的防治作用。

The preventive effect of local application of hirudin on expanded flap venous congestion

Objective To evaluate the effect of locally applied hirudin on the expanded flap venous congestion.Methods Mini pigs were employed to establish expanded model.Expanded congestive flaps were divided into 3 groups: Group A(locally applied 0.5?U native hirudin/each flap),Group B(locally applied 1U native hirudin/each flap) and control group.Macroscopic observation were done and pathological section were examined under microscope.ET-1,NO,TXB_2 level were measured.Results Flap ongestion in medication group(Group A and Group B have no difference) disappeared more quickly after operation than control group.Under the microscope,congestion degree in medication group had singnificant difference compared with control group during similar period.Tissue ET-1,NO,TXB_2 level in medication group were significantly different compared with control group(P<0.05).Conclusion Local application of hirudin had singnificant preventive effect on expanded flap congestion.