282例宫颈癌前病变快速 HPV 基因检查的结果分析

目的：评价人乳头瘤病毒（HPV）检测在筛查女性早期宫颈癌前病变中的临床研究价值。方法对282例宫颈筛查的患者行宫颈的脱落细胞采集，同时做液基薄层细胞学（TCT）检查及 HPV 基因分型检测。对结果异常者行病理组织学检查，以病理检查结果为诊断金标准。结果HPV DNA 阳性组（126例）液基细胞学检查无上皮内病变细胞（NILM）53例、意义不明确的非典型鳞状上皮细胞（ASCUS）22例、低度鳞状上皮内病变（LSIL）32例、高度鳞状上皮内病变（HSIL）18例、鳞状细胞癌（SCC）1例，病理组织检查阳性率为42．86％。HPV DNA 阴性组（156例）液基细胞学检查 NILM 133例、ASCUS 16例、LSIL 7例，病理组织检查阳性率为11．54％。2组患者病理阳性率比较，差异有统计学意义（P ＜0．01）。高危型 HPV 的检出率随宫颈病变程度增高而升高。结论女性早期宫颈癌及其癌前病变筛查行 HPV 检测有重要现实意义。

The results analysis of the rapid detection of HPV genetype in 282 cervical cancer precursor cases

Objective To evaluate the clinical values of human papilloma virus（HPV）testing in screening for women of early cervical cancer lesion.Methods 282 cases of cervical screening of patients had received cervical exfoliated cells collection,at the same time for a liquid thin-layer cytology test（TCT）and HPV genotyping detection.Abnormal results received histologic examination,the results regarded as the diagnostic gold standard by pathological examination.Results In HPV DNA positive group（126 cases）,by liquid based cytology,NILM,ASCUS,LSIL,HSIL and SCC were found in 53,22,32,18,1 cases,respectively.Histopathologic examination positive rate was 42.86%.In HPV DNA negative group（156 cases）,there were 133 cases with NILM,16 cases with ASCUS,and 7 cases with LSIL.Histopathologic examination positive rate was 11.54%.Two groups of patients with pathologic positive rate compared,the difference was statistically significant（P 〈0.01 ）.High risk type HPV detection rate increased with the increased degree of cervical lesions.Conclusion Women of early cervical cancer and precancerous lesions in the screening line HPV detection has important significance.