降钙素原和C反应蛋白测定在新生儿败血症患者中的临床应用

目的：探讨降钙素原（PCT）和 C 反应蛋白（CRP）测定在新生儿败血症患者中的临床应用价值。方法选取50例败血症新生儿为观察组，同期的50例健康新生儿为对照组，然后将2组血清 PCT 和 CRP 水平与阳性率进行比较，同时分析2种指标单用及联合应用的特异度、敏感度、阴性及阳性预测值。结果观察组患儿的血清 PCT 和 CRP 水平与阳性率均高于对照组健康新生儿（P ＜0．05），2种指标联合检测的特异度及阳性预测值高于 PCT 和 CRP 单用检测，差异均有统计学意义（P ＜0．05）。结论PCT 和 CRP 测定在新生儿败血症患者中的临床应用价值较高，联合应用有助于提高早期诊断率，并可作为疾病治疗效果的判断依据。

Clinical application of the procalcitonin and C reactive protein detection in the newborns with septicemia

Objective To investigate the clinical application value of procalcitonin（PCT）and C reactive protein（CRP）detection in the newborns with septicemia.Methods 50 newborns with septicemia in the hospital were enrolled as the observation group,and 50 healthy newborns at the same period were enrolled as the control group.Then the serum PCT and CRP levels and positive rates of two groups were detected and compared.The specificity,sensitivity,negative predictive values and positive predictive values of two indexes′single and combined application were analyzed,too.Results The serum PCT and CRP levels and positive rates of observation group were all higher than those of control group,and the specificity and positive predictive values of two indexes′combined application were all higher than those of PCT and CRP single application（P 〈0.05）.Conclusion The clinical application values of PCT and CRP detection in the newborns with septicemia are high.The combined application is helpful for the early diagnosis,it also can be as the curative effect of disease treatment effect.