三种NSAIDS对活动期强直性脊柱炎患者疼痛的疗效及安全性评价

目的：探讨三种非甾体抗炎药物（NSAIDs）尼美舒利、美洛昔康及塞来昔布对活动期强直性脊柱炎（AS）患者疼痛的疗效及安全性。方法：60例活动期AS患者,服药时间从活动期开始到非活动期停用,随机分为三组,A组（尼美舒利）23例、B组（美洛昔康）21例及C组（塞来昔布）16例。比较治疗前后患者的总体疼痛评分VAS、夜间痛、脊柱痛分级变化,并评价三种NSAIDS的总体止痛疗效及安全性。结果：治疗前后患者的总体疼痛评分VAS、夜间痛、脊柱痛分级变化差异显著（P〈0.01）,治疗后A、B、C组缓解疼痛的总有效率分别为73.9%、76.2%及87.5%,三组比较无显著差异（P〉0.05）;三组总不良反应发生率分别为13.0%、23.8%及6.3%,C组低于A及B组,但三组间差异无显著性（P〉0.05）。不良反应主要集中在胃肠道,无严重心脑血管不良事件发生。结论：尼美舒利、美洛昔康及塞来昔布对活动期AS患者止痛疗效及安全性相似,均具有疗效好、安全性高、患者耐受性好的特点。

ESTIMATE OF THE EFFICACY AND SAFETY OF THREE KINDS OF NSAIDS IN EASING THE ACHE OF ACTIVE ANKYLOSING SPONDYLITIS PATIENTS

Objective: To evaluate the efficacy and safety of three kinds of nonsteroidal antiinflammatory drugs(NSAIDs) in sufferers of active ankylosing spondylitis(AS).Methods: 60 cases of active AS sufferers,who have been dosed from active time to rest time,were divided into three groups in random,23 cases in A group(nimesulide),21cases in B group(meloxicam) and 16 cases in C group(celecoxib).The changes of total ache evaluate(visual analogue scale, VAS),grades of night ache and spine ache were observed,and the total acesodyne efficacy and safety were evaluated.Results: The total ache VAS,grades of night ache and spine ache were improved significantly after treatment(P<0.01).The total effective ratio of easing ache was 73.9%,76.2% and 87.5% respectively,with no significant differences(P>0.05).The rate of side effects was 13.0%,23.8% and 6.3% respectively,with no significant differences(P>0.05).The side effects mainly focused on stomach and intestines,with no severe side effects.Conclusion: Nimesulide,meloxicam and celecoxib were similar to active AS patients in the efficacy and safety,and all possessed superior effects,high security and good tolerance.