Endogenous phosphorylation of lysosomal proteins of rat heart and liver in the early postreanimation period |
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Authors: | T N Ivanova E D Polyakova S E Nikulina L V Molchanova |
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Institution: | (1) Institute of Biomedical Chemistry, Russian Academy of Medical Sciences, Moscow;(2) Institute of General Reanimatology, Russian Academy of Medical Sciences, Moscow |
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Abstract: | The lysosomal fraction isolated in a Percoll gradient from rat liver and heart after 30 min of the postreanimation period
following a 5-min heart arrest stimulated incorporation of32P in total lysosomal protein. Addition of cAMP and protein inhibitor of cAMP-dependent protein kinase changed the rate of
phosphorylation. Endogenous phosphorylation of total lysosomal protein in the postreanimation period was reduced in the heart
and increased in the liver. This may be due to a change in the intracellular level of cAMP, which fell in the heart and rose
in the liver.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, N
o
7, pp. 51–53, July, 1995
Presented by A. I. Archakov, Member of the Russian Academy of Medical Sciences |
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Keywords: | lysosomes cAMP-dependent phosphorylation postreanimation period heart liver |
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