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| 酮基布洛芬的合成方法改进 | |
| 引用本文： | 余红霞,郭峰,陈芬儿. 酮基布洛芬的合成方法改进[J]. 中国药物化学杂志, 2003, 13(2): 97-98,101 |
| 作者姓名： | 余红霞 郭峰 陈芬儿 |
| 作者单位： | 1. 武汉化工学院制药系,湖北,武汉,430073 2. 中国药科大学药学院,江苏,南京,210009 3. 复旦大学化学系,上海,200433 |
| 摘 要： | 目的 合成酮基布洛芬，提高产品纯度。方法 以3—苄基苯乙酮为原料，通过Darzens缩合，氧化合成目标物。结果与结论 以3—苄基苯乙酮计算，总收率约64％，产品纯度为99．8％。并通过红外吸收光谱(IR)、质谱(Ms)确证了目标物的结构。该合成工艺简单，产品质量好。 |
| 关 键 词： | 药物化学 工艺改进 Darzens缩合 酮基布洛芬 非甾体消炎药 |
| 文章编号： | 1005-0108(2003)02-0097-02 |
Improved synthesis of ketoprofen |
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| YU Hong xia ,GUO Feng ,CHEN Fen er. Improved synthesis of ketoprofen[J]. Chinese Journal of Medicinal Chemistry, 2003, 13(2): 97-98,101 | |
| Authors: | YU Hong xia GUO Feng CHEN Fen er |
| Affiliation: | YU Hong xia 1,GUO Feng 2,CHEN Fen er 3 |
| Abstract: | Aim To synthesize and improve the purity of ketoprofen.Methods The target compound was synthesized from 3 benzylacetophenone via Darzens condensation and oxidation.Results and Conclusion The overall yield was about 64% and the purity of the product was 99 8%.The structure was established by IR and MS.The synthetic technique is comparably simpler with better quality of the product. |
| Keywords: | medicinal chemistry process improvement Darzens condensation ketoprofen |
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