| 乳腺癌p16、PS2基因表达与多药耐药的相关分析 |
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| 引用本文： | 童淑兰,耿志坚,费绍华,叶龙珍,殷梅英,杨玲芳,孙宏夫. 乳腺癌p16、PS2基因表达与多药耐药的相关分析[J]. 肿瘤防治研究, 2003, 30(4): 282-284 |
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| 作者姓名： | 童淑兰 耿志坚 费绍华 叶龙珍 殷梅英 杨玲芳 孙宏夫 |
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| 作者单位： | 200135,上海浦东新区公利医院 |
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| 摘 要： | 目的 探讨乳腺癌中 p16、PS2与GST Pi、TOPOⅡ、PgP表达意义及相关性。 方法 用即用型微波加热免疫组化法对 5 7例乳癌进行p16、PS2、GST Pi、TOPOⅡ、PgP检测分析。 结果 5 7例乳癌的阳性率依次为 36 .84 %、77.19%、5 2 .6 3%、2 4 .5 6 %、15 .79%。结论 乳癌产生多药耐药性可能与 p16、PS2异常表达相关。部分乳癌患者体内存在多项耐药基因或癌细胞内原发存在对GST Pi、TOPOⅡ、PgP介导的抗癌药物耐药。
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| 关 键 词： | 乳腺癌 p16 PS2基因蛋白 耐药基因 免疫组化 |
| 文章编号： | 1000-8578(2003)04-0282-03 |
| 收稿时间： | 2002-07-16 |
| 修稿时间： | 2002-07-16 |
Relationship between expression of p16、PS2 and multidrug resistance in breast cancer |
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| TONG Shu-lan,GENG Zhi-jian,FEI Shao-hua,et al Gongli Hospital of Pudong New Area of Shanghai,Shanghai ,China. Relationship between expression of p16、PS2 and multidrug resistance in breast cancer[J]. Cancer Research on Prevention and Treatment, 2003, 30(4): 282-284 |
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| Authors: | TONG Shu-lan GENG Zhi-jian FEI Shao-hua et al Gongli Hospital of Pudong New Area of Shanghai Shanghai China |
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| Affiliation: | TONG Shu-lan,GENG Zhi-jian,FEI Shao-hua,et al Gongli Hospital of Pudong New Area of Shanghai,Shanghai 200135,China |
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| Abstract: | Objective To explore the relationship between expression of p16、PS2 and Resistance genes of GST-Pi、TOPOII、 PgP in breast cancer. Methods The detection and analysis of p16、PS2、GST-Pi、TOPOII、PgP genes proteins in 57 breast cancer were made by using the Instant Microwave heating-immunohistochistry technique. Results The positive expression rate of p16、PS2、GST-Pi、TOPOII、PgP are 36.84% 77.19%, 52.63%, 24.56%, 15.79%, respectively in breast cancer of 57 cases. Conclusion Abnorm... |
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| Keywords: | Breast carcinoma Gene protein-p16 PS2 Multidrug resistance Immunohistochmistry |
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