胃癌发生部位及组织学类型的转变趋势（附350例分析）

本文分别观察并研究了１９８５～１９８９（ｎ＝１３１）和１９９０～１９９４（ｎ＝２１９），共３５０例经手术和组织学确诊的胃癌癌病人，其目的主要是确定前后五年间胃癌的发生部位及组织学有否发生改变。依时间先后顺序将观察病例分为Ａ、Ｂ两组。结果显示近５年来（Ｂ组）贲门、胃底癌发生比例（０．５０）较前５年（Ａ组）发生比例（０．３３）显著升高（Ｐ＜０．００５）。此外组织学检查表明Ｂ组病例中分化差的腺癌发生比例（０．７０）也较Ａ组（０．５８）明显升高（Ｐ＜０．０５）。研究分析提示，近端胃癌发生比例增高趋势可能与吸烟因素有关；而分化差胃癌发生比例的增高则是一种值得重视的胃癌组织学改变。

Developing parts of stomach cancer and increasing tendency of adenocarcinoma(Analysis of 350 cases)

History of 350 cases of carcinoma of stomach diagnosed by operation and their histology were studied from 1985 to 1989(group A,n=131) and from 1990 to 1994(group B,n=219).The aims was to detetmine whether there were some differences in developing parts and histologic changes between this two periods.According to the order of time,the cases were devided into two groups.The results showed that the percentage of carcinoma of cardia and fundus of stomach in group B(50%) was much higher than that(33%) in group A (p<0.005).Histologie examination showed that the percentage(70%) of the badly differentiated adenocarcinoma in group B was much higher than that in group A(58%,p<0.025).Analysis of this study showed that the increasing tendency of carcinoma at proximal ends of the stomach possibly related with he factor of smoking.The increase in morbidity of adenocareinoma of the stomach should be considcred as an important historic change in carcinoma of the stomach,however,its mechanism should to investigate.