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Amyotrophic lateral sclerosis: the Midwestern surgical experience with the diaphragm pacing stimulation system shows that general anesthesia can be safely performed |
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| Authors: | Raymond P. Onders Arthur M. Carlin MaryJo Elmo Subhalakashmi Sivashankaran Bashar Katirji Robert Schilz |
| Affiliation: | a Department of Surgery, University Hospitals Case Medical Center, Detroit, MI, USA b Neurologic Institute, University Hospitals Case Medical Center, Detroit, MI, USA c Department of Surgery, Henry Ford Health Systems, Detroit, MI, USA d Department of Anesthesia, University, Hospitals Case Medical Center, Cleveland, OH, USA e Department of Medicine, University, Hospitals Case Medical Center, Cleveland, OH, USA |
| Abstract: | BackgroundThere is a paucity of literature concerning general anesthesia and surgery in patients with amyotrophic lateral sclerosis (ALS or Lou Gehrig's disease). This report summarizes the largest series of surgical cases in ALS during multicenter prospective trials of the laparoscopic diaphragm pacing system (DPS) to delay respiratory failure.MethodThe overall strategy outlined includes the use of rapidly reversible short-acting analgesic and amnestic agents with no neuromuscular relaxants.ResultsFifty-one patients were implanted from March 2005 to March 2008 at 2 sites. Age at implantation ranged from 42 to 73 years and the percent predicted forced vital capacity (FVC) ranged from 20% to 87%. On preoperative blood gases, Pco2 was as high as 60. Using this protocol, there were no failures to extubate or 30-day mortalities. The DPS system increases the respiratory system compliance by decreasing posterior lobe atelectasis and can stimulate respirations at the end of each case.ConclusionsLaparoscopic surgery with general anesthesia can be safely performed in patients with ALS undergoing DPS. |
| Keywords: | Amyotrophic lateral sclerosis Diaphragm pacing Perioperative management |
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