Paradoxical antagonism by bicuculline of the inhibition by baclofen of the electrically evoked release of [3H]GABA from rat cerebral cortex slices |
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| Authors: | Y Maurin |
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| Institution: | Department of Biology, Laboratoire d'Etudes et de Recherches Synthélabo, Paris, France. |
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| Abstract: | The presynaptic regulation of the electrically evoked release of 3H]GABA was studied in the rat cerebral cortex. Among the GABA receptor agonists tested (GABA, SL 75102, muscimol, THIP, isoguvacine, (+/-)-baclofen), only (+/-)-baclofen inhibited the stimulation-evoked release of 3H]GABA. This effect of baclofen was stereoselective in favor of the (-) enantiomer. The inhibition by (+/-)-baclofen of the electrically evoked release of 3H]GABA was antagonized by bicuculline and picrotoxin. Our results suggest that the release of 3H]GABA in vitro can be modulated by a receptor-mediated mechanism which is sensitive to baclofen, bicuculline and picrotoxin but not to GABA, muscimol or THIP. |
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