The influence of the sesquiterpene lactones from Geigeria on mast cell degranulation |
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| Authors: | A R Gaspar J A Verschoor A W Neitz N M Vermeulen |
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| Institution: | 1. Division of Allergy and Immunology, Department of Pediatrics, University of South Florida at Johns Hopkins - All Children''s Hospital, St Petersburg, Fla;2. Department of Pediatrics, Hiroshima University Graduate School of Biomedical & Health Sciences, Hiroshima, Japan;3. Department of Pediatrics, University of Washington and Seattle Children''s Research Institute, Seattle, Wash;4. Great North Children''s Hospital, RVI, Newcastle upon Tyne, United Kingdom;5. Primary Immunodeficiency Group, ICM, Newcastle University, Newcastle upon Tyne, United Kingdom;6. Federal Research and Clinical Center for Pediatric Hematology, Oncology, and Immunology, Moscow, Russia;7. Canadian Center for Primary Immunodeficiency, Hospital for Sick Children, Toronto, Ontario, Canada;8. Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, University of Utah, Salt Lake City, Utah;9. Division of Hematology, Oncology, and Blood and Marrow Transplantation, Children''s Hospital Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, Calif;10. Regional Immunology Service, Royal Hospitals, Belfast, United Kingdom;11. Department of Pediatrics, Royal Hospitals, Belfast, United Kingdom;12. Center for Chronic Immunodeficiency, University Medical Center Freiburg and University of Freiburg, Freiburg, Germany;13. Pediatric Blood and Marrow Transplantation Program, University Medical Center Utrecht, Utrecht, The Netherlands;14. Blood and Bone Marrow Transplant Program, Johns Hopkins Medicine–All Children''s Hospital, St Petersburg, Fla;15. Division of Allergy and Immunology, University of Pennsylvania Perelman School of Medicine and the Children''s Hospital of Philadelphia, Philadelphia, Pa;p. Division of Oncology, Department of Pediatrics, University of Pennsylvania Perelman School of Medicine and the Children''s Hospital of Philadelphia, Philadelphia, Pa;q. Division of Pediatric Immunology, Department of Pediatrics, Uludag University Medical Faculty, Gorukle-Bursa, Turkey;r. GATA Faculty, Bone Marrow Transplant Center, Ankara, Turkey;s. Department of Immunology, Hospital de la Sant Creu i Sant Pau, Barcelona, Spain;t. Allergy and Immunology, Hospital Rebagliati, Lima, Peru;u. Department of Pediatrics and Developmental Biology, Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Tokyo, Japan;v. Department of Pediatrics, Hokkaido University Graduate School of Medicine, Sapporo, Japan;1. Baylor-Hopkins Center for Mendelian Genomics of the Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Tex;2. Center for Human Immunobiology of Texas Children''s Hospital/Department of Pediatrics, Baylor College of Medicine, Houston, Tex;10. Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Tex;11. Human Genome Sequencing Center, Baylor College of Medicine, Houston, Tex;12. Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine, Houston, Tex;t. Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Tex;3. Department of Pediatrics, Division of Immunology, Allergy, and Rheumatology, Baylor College of Medicine, and Texas Children''s Hospital, Houston, Tex;4. Norwegian National Unit for Newborn Screening, Oslo University Hospital, Oslo, Norway;5. Department of Pediatrics, Oslo University Hospital, Oslo, Norway;6. Department of Medical Genetics, Oslo University Hospital, Oslo, Norway;15. Department of Hematology, Oslo University Hospital, Oslo, Norway;s. Department of Immunology and Transfusion Medicine, Oslo University Hospital, Oslo, Norway;1515. Department of Rheumatology, Oslo University Hospital, Oslo, Norway;7. Institute of Clinical Medicine, University of Oslo, Oslo, Norway;8. Institute of Computer Science, Warsaw University of Technology, Warsaw, Poland;9. Department of Pediatrics, Baylor College of Medicine, and Texas Children''s Hospital, Houston, Tex;13. Texas Children''s Cancer and Hematology Center, Department of Pediatrics, Center for Cell and Gene Therapy, Texas Children''s Hospital and Baylor College of Medicine, Houston, Tex;14. Section of Clinical Immunology and Infectious Diseases, Oslo University Hospital Rikshospitalet, Oslo, Norway;p. Department of Hematology, St Olavs Hospital, Trondheim, Norway;q. Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway;r. Department of Infectious Diseases, Medical Clinic, University Hospital of North-Norway, Tromsø, Norway;u. Immunology Service, Ricardo Gutierrez Children''s Hospital, Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina;v. Immunodeficiencies Research Unit, National Institute of Pediatrics, Coyoacan, Mexico City, Mexico;w. Universidad San Francisco de Quito, Quito, Ecuador;x. Hospital Roberto del Rio, Universidad de Chile, Santiago, Chile;y. Grupo de Inmunodeficiencias Primarias, Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad de Antioquia UdeA, Medellin, Colombia;z. Allergy and Clinical Immunology, Hospital Nacional Edgardo Rebagliati Martins, Lima, Peru;11. Alberta Children''s Hospital, Calgary, Alberta, Canada;22. Department of Pediatrics, Dalhousie University, Izaak Walton Killam Health Centre, Halifax, Nova Scotia, Canada;33. Department of Pediatrics, National Jewish Health, Denver, Colo;44. Section of Pulmonary, Critical Care, Allergic and Immunological Diseases, Wake Forest Baptist Medical Center, Medical Center Boulevard, Winston-Salem, NC;55. Department of Pediatrics, Division of Pediatric Allergy/Immunology and Pulmonology, University of Iowa Carver College of Medicine, Iowa City, Iowa;66. Department of Pediatrics, University of California, San Francisco, Calif;77. San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), and Vita-Salute San Raffaele University, Milan, Italy;88. University Department of Pediatrics, DPUO, Bambino Gesù Children''s Hospital, and Tor Vergata University, Rome, Italy;99. Department of Clinical Genetics, University Hospital of Umeå, Umeå, Sweden;1010. Department of Clinical Sciences, Pediatrics, Umeå University, Umeå, Sweden;1111. Department of Medical Genetics, Bezmi Alem Vakif University Faculty of Medicine, Istanbul, Turkey;1212. Department of Pediatric Immunology and Allergy, Selcuk University Medical Faculty, Alaeddin Keykubat Kampusu, Konya, Turkey;1313. Department of Pediatrics, Section of Pediatric Allergy and Immunology, Hamad Medical Corporation, Doha, Department of Paediatrics, Weill Cornell Medical College, Ar-Rayyan, Qatar;1414. Immunodeficiency Centre for Wales, University Hospital of Wales, Cardiff, Wales;pp. Human Genetics Center, University of Texas School of Public Health, Houston, Tex;1. Centralized Sequencing Program, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, Bethesda, Md;2. Bioinformatics and Computational Biosciences Office of Cyber Infrastructure and Computational Biology, National Institute of Allergy and Infectious Diseases, Bethesda, Md;3. Operations and Engineering Branch, Office of Cyber Infrastructure and Computational Biology, National Institute of Allergy and Infectious Diseases, Bethesda, Md;4. Fungal Pathogenesis Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, Md;5. Immunopathogenesis Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, Md;6. Genetic Immunotherapy Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, Md;7. Clinical Mycology, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, Md;8. Epithelial Therapeutics Unit, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, Md;9. Laboratory of Host Defenses, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, Md;10. Mucosal Immunity Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, Md;11. Neuroimmunological Diseases Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, Md;12. Translational Autoinflammatory Disease Studies Unit, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, Md;13. Translational Mycology Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, Md;14. Immune Deficiency Genetics Diseases Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, Md;15. Human Immunological Diseases Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, Md;p. Primary Immune Deficiency Clinic (Autoimmune Lymphoproliferative Syndrome Clinic), Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, Md;q. Food Allergy Research Unit, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Md;r. Mast Cell Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Md;s. Lung and Vascular Inflammation Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Md;t. Translational Allergic Immunopathology Unit, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Md;u. HIV Pathogenesis Section Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda, Md;v. Medical Virology Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda, Md;w. Human Eosinophil Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Md;x. Helminth Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Md;y. Molecular Signaling Section, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, Bethesda, Md;z. Functional Immunogenomics Unit, Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Md;11. Genetics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Md;12. Department of Bioethics, National Institutes of Health Clinical Center, Bethesda, Md;13. Laboratory Medicine, National Institutes of Health Clinical Center, Bethesda, Md;14. Microbiology Service, Laboratory Medicine, National Institutes of Health Clinical Center, Bethesda, Md;15. Immunology Service, Laboratory Medicine, National Institutes of Health Clinical Center, Bethesda, Md;16. School of Medicine, Uniformed Services University of Health Sciences, Bethesda, Md;17. Center for Precision Health Research, National Human Genome Research Institute, Bethesda, Md;18. Cardiovascular and Pulmonary Branch, National Heart, Lung, and Blood Institute, Bethesda, Md;19. Johns Hopkins/NIH Genetic Counseling Training Program, Bethesda, Md;110. Health, Behavior, and Society, Johns Hopkins Bloomberg School of Public Health, Baltimore, Md;111. College of Medicine, Penn State, University Park, Pa;112. School of Medicine, University of Miami, Miami, Fla;113. Institute of Genomic Medicine, Columbia University, New York, NY;114. NIAID Collaborative Bioinformatics Resource, Leidos Biomedical Research, Inc, Frederick, Md;115. Department of Molecular and Human Genetics, Baylor Genetics, Houston, Tex;1p. Division of Allergy and Immunology, Children''s National Health System, Washington, DC |
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| Abstract: | The sesquiterpene lactones isolated from Geigeria were found to be incapable of inducing rat peritoneal mast cell degranulation at levels of 0.3-1.6 mM. The sulphydryl reagent, N-ethylmaleimide, too was unable to trigger mast cell secretion. Instead, it was observed that these compounds inhibited the release of histamine induced by Compound 48/80. Pretreatment of the lactones and N-ethylmaleimide with the amino acid, L-cysteine, reduced their inhibition ability of histamine release to a considerable extent, but not completely. Geigerin(V), which lacks an alpha-methylene group and the chemically prepared cysteine-adduct of dihydrogriesenin(I), were also capable of inhibiting mast cell secretion by Compound 48/80, but to a lesser extent. |
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