A single nucleotide polymorphism in the alcohol dehydrogenase 7 gene (alanine to glycine substitution at amino acid 92) is associated with the risk of squamous cell carcinoma of the head and neck |
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Authors: | Sheng Wei MD PhD Zhensheng Liu MD PhD Hui Zhao MD PhD Jiangong Niu PhD Li‐E Wang MD PhD Adel K El‐Naggar MD PhD Erich M Sturgis MD Qingyi Wei MD PhD |
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Institution: | 1. Department of Epidemiology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas;2. Department of Pathology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas;3. Department of Head and Neck Surgery, The University of Texas M. D. Anderson Cancer Center, Houston, Texas;4. Department of Epidemiology, The University of Texas M. D. Anderson Cancer Center, Houston, TexasFax: (713) 563‐0999 |
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Abstract: | BACKGROUND: The authors conducted a hospital‐based study of 1110 patients with squamous cell carcinoma of the head and neck (SCCHN) and a control group of 1129 patients to replicate the associations reported by a recent, large European study between 2 potentially functional single nucleotide polymorphisms (SNPs) of the alcohol dehydrogenase (ADH) genes, a substitution in ADH1B at amino acid 48 from arginine to histidine (R48H) (reference SNP number rs]1229984; guanine to adenine G→A]) and a substitution in ADH7 at amino acid 92 from alanine to glycine (A92G) (rs1573496; cytosine to guanine C→G]), and the risk of squamous cell carcinoma of the head and neck (SCCHN). METHODS: Multivariate logistic regression was used to calculate adjusted odds ratios (ORs) and 95% confidence intervals (CIs). False‐positive report probabilities (FPRPs) also were calculated for significant findings. RESULTS: The ADH7 A92G GG and combined CG + GG genotypes were associated with a decreased risk of SCCHN (GG: adjusted OR, 0.32; 95% CI, 0.13‐0.82; CG + GG: adjusted OR, 0.74; 95% CI, 0.59‐0.94; FPRP, .098) compared with the CC genotype. This association was also evident in subgroups of older patients (aged >57 years), men, former smokers, patients with oral cancer, and patients with N) lymph node status (P < .05 for all); however, such associations were not observed for the ADH1B R48H SNP. CONCLUSIONS: The current results support the ADH7 A92G SNP as a marker for the risk of SCCHN in non‐Hispanic white populations. Cancer 2010. © 2010 American Cancer Society. |
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Keywords: | ADH7 genetic variant genetic susceptibility head and neck cancer molecular epidemiology |
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