Preoperative prealbumin level as an independent predictor of long-term prognosis after liver resection for hepatocellular carcinoma: a multi-institutional study |
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| Authors: | Ju-Dong Li Xin-Fei Xu Jun Han Han Wu Hao Xing Chao Li Jiong-Jie Yu Ya-Hao Zhou Wei-Min Gu Hong Wang Ting-Hao Chen Yong-Yi Zeng Wan Y Lau Meng-Chao Wu Feng Shen Tian Yang |
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| Institution: | 1. Department of Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China;2. Department of Clinical Medicine, Second Military Medical University, Shanghai, China;3. Department of Hepatobiliary Surgery, Pu''er People''s Hospital, Yunnan, China;4. The First Department of General Surgery, The Fourth Hospital of Harbin, Heilongjiang, China;5. Department of General Surgery, Liuyang People''s Hospital, Hunan, China;6. Department of General Surgery, Ziyang First People''s Hospital, Sichuan, China;7. Department of Hepatobiliary Surgery, Mengchao Hepatobiliary Hospital, Fujian Medical University, Fujian, China;8. Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China |
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| Abstract: | BackgroundSerum prealbumin is a sensitive and stable marker for nutritional status and liver function. Whether preoperative prealbumin level is associated with long-term prognosis in patients undergoing liver resection for hepatocellular carcinoma (HCC) is unclear.MethodsPatients who underwent liver resection for HCC between 2001 and 2014 at six institutions were enrolled. These patients were divided into the low and normal prealbumin groups using a cut-off value of 170 mg/L for preoperative prealbumin level. The overall survival (OS) and recurrence-free survival (RFS) were compared between them.ResultsIn 1483 patients, 437 (29%) had a low prealbumin level. The 3- and 5-year OS and RFS rates of patients in the low-prealbumin group were 57 and 31%, and 40 and 20%, respectively, which were significantly poorer than those in the normal-prealbumin group (76 and 43%, and 56 and 28%, respectively, both p < 0.001). Multivariable Cox-regression analyses revealed that preoperative prealbumin level was an independent predictor of OS (HR, 1.45, 95% CI: 1.24–1.70, p <0.001) and RFS (HR, 1.28, 95% CI: 1.10–1.48, p <0.001).ConclusionsPreoperative prealbumin level could be used in predicting long-term prognosis for patients undergoing liver resection for HCC. |
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| Keywords: | Correspondence: Tian Yang Feng Shen Department of Hepatobiliary Surgery Eastern Hepatobiliary Surgery Hospital Second Military Medical University No 225 Changhai Road Shanghai 200438 China |
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