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Flow cytometric detection of Pig‐A mutant red blood cells using an erythroid‐specific antibody: Application of the method for evaluating the in vivo genotoxicity of methylphenidate in adolescent rats
Authors:Vasily N Dobrovolsky  Sherin Y Boctor  Nathan C Twaddle  Daniel R Doerge  Michelle E Bishop  Mugimane G Manjanatha  Takafumi Kimoto  Daishiro Miura  Robert H Heflich  Sherry A Ferguson
Institution:1. Division of Genetic and Reproductive Toxicology;2. National Center for Toxicological Research/U.S. Food and Drug Administration, Jefferson, Arkansas;3. Division of Neurotoxicology, National Center for Toxicological Research/U.S. Food and Drug Administration, Jefferson, Arkansas;4. Department of Interdisciplinary Biomedical Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas;5. Division of Biochemical Toxicology, National Center for Toxicological Research/U.S. Food and Drug Administration, Jefferson, Arkansas;6. Teijin Pharma, Ltd., 4‐3‐2, Asahigaoka, Hino, Tokyo 191‐8512, Japan
Abstract:
Keywords:HIS49  Sprague‐Dawley rats  N‐ethyl‐N‐nitrosourea  micronucleus  glycosyl phosphotidylinositol anchor  ritalinic acid
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