| 脑络通对气虚血瘀证脑缺血大鼠作用机理研究 |
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| 引用本文： | 王键 胡建鹏. 脑络通对气虚血瘀证脑缺血大鼠作用机理研究[J]. 安徽中医学院学报, 1999, 18(5): 73-75 |
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| 作者姓名： | 王键 胡建鹏 |
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| 作者单位： | 安徽中医学院!合肥230038 |
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| 摘 要： | 目的：探讨脑络通对气虚血瘀证脑缺血大鼠作用机理，为脑络通的临床应用提供实验依据。方法：采用多因素病证结合气虚血瘀脑缺血大鼠模型，观察了局部脑组织血流量（ｒＣＢＦ），脑水肿，血流流变性，血浆血栓素Ａ２（ＴＸＡ２）及前列环素（ＰＧＩ２）的变化，结果：脑络通能显著增加模型鼠ｒＣＢＦ，减轻脑水肿程度（Ｐ〈０．０１），能显著改善模型鼠血流变性，能显著降低模型鼠血浆ＴＸＢ２水平，升高ＰＧＩ２水平（Ｐ〈０．０５
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| 关 键 词： | 脑络通 气虚血瘀 脑缺血 血液流变性 |
THERAPEUTIC EFFECT OF NAOLUOTONG TREATMENT ON QI DEFICIENCY AND BLOOD STASIS OF CEREBRAL ISCHEMIA IN RATS |
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| Abstract: | Objective:In the present study the authors investigated the therapeutic effects of Naoluotong on Qi deficiency and blood stasis type of cerebral ischemia in rats,in order to provide the laboratory evidence for the clinical usage.Method:The Qi deficiency and blood stasis type of cerebral ischemia rats were used.The regional cerebral blood flow (rCBF),edema and hemorheology were observed.The contents of thromboxane A 2(TXA 2) and prostacycline(PGI 2) in plasm were detected.Result:Naoluotong could remarkably increase rCBF and decrease the cerebral water content in cerebral ischemia rats,improve hemorheology properites in cerebral ischemia rats;and could remarkably decrease the TXA 2 content of plasma and increase the PGI 2 content of plasma in cerebral ischemia rats.Conclusion:Above results suggest that Naoluotong have therapeutic effects on Qi deficiency and blood stasis of cerebral ischemia in rats. |
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| Keywords: | Naoluotong Qi deficiency and blood stasis Cerebral ischemia Cerebral edema Regional cerebral blood flow Hemorheology Thromboxane A 2 Prostacycline |
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