Association between history of abortion and nonalcoholic fatty liver disease in middle-aged and elderly Chinese women |
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| Authors: | Yu Liu Jieli Lu Min Xu Yu Xu Mian Li Tiange Wang Jie Zhang Baihui Xu Jichao Sun Meng Dai Yufang Bi Weiqing Wang Guang Ning |
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| Institution: | 1. Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, E-Institute of Shanghai Universities, Shanghai, China;2. Department of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai, China;1. Department of Endocrinology, Research Center of Excellence AmbiSEN, University of Pisa, Pisa, Italy;2. Department of Reproductive Medicine and Child Development, Division of Obstetrics and Gynecology, University of Pisa, Pisa, Italy;3. Mother and Child Department, Cytogenetics and Molecular Genetic Unit, University Hospital of Pisa, Pisa, Italy;1. Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin;2. Department of Population Health Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin;3. Division of Human Genetics, Cincinnati Children''s Hospital Medical Center, Cincinnati, Ohio;4. Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio;5. Department of Biostatistics and Medical Informatics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin;1. Center for the Study of Atherosclerosis, Bassini Hospital, Cinisello Balsamo, Milan, Italy;2. Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milan, Italy;3. Dipartimento di Medicina Interna, Centro Studi Malattie Metaboliche del Fegato – Cà Granda IRCCS Fondazione Ospedale Policlinico, Milan, Italy;4. William Harvey Research Institute, Barts and The London School of Medicine & Dentistry Queen''s Mary University, London, United Kingdom;5. Multimedica Hospital – IRCCS, Sesto San Giovanni, Milan, Italy;1. Prince of Wales Clinical School, University of New South Wales, Sydney, Australia;2. School of Medical Sciences, University of New South Wales, Sydney, Australia;3. St Elisabeth Ziekenhuis, Tilburg, The Netherlands;4. Department of Geriatrics, Neurosciences and Orthopaedics, Università Cattolica del Sacro Cuore, Rome, Italy;5. Don Gnocchi Foundation, Milan, Italy;6. St Vincent’s Clinical School, University of New South Wales, Darlinghurst, NSW, Australia;7. Brain and Mind Centre, University of Sydney, Sydney, Australia;1. Radiology Unit, Department of Diagnostic Imaging, Radiant and Metabolic Therapy, “Istituto Nazionale Tumori Fondazione Giovanni Pascale – IRCCS”, Naples, Italy;2. Department of Advanced Biomedical Sciences, Federico II University of Naples, Naples, Italy;3. Pathology Unit, Department of Diagnostic and Laboratory Pathology, “Istituto Nazionale Tumori Fondazione Giovanni Pascale – IRCCS”, Naples, Italy;4. Senology Surgery Unit, Department of Senology, “Istituto Nazionale Tumori Fondazione Giovanni Pascale – IRCCS”, Naples, Italy |
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| Abstract: | PurposeTo evaluate the possible relationship between self-reported history of abortion and nonalcoholic fatty liver disease (NAFLD) in middle-aged and elderly Chinese women.MethodsA cross-sectional study was performed in 5911 women aged 40 years or older in Jiading District, Shanghai, China. Reproductive histories, including miscarriage and induced abortion, were collected using a validated questionnaire by trained physicians. Abdominal B-mode ultrasound evaluation and serum liver enzymes levels were used in the diagnosis of NAFLD.ResultsThe percentage reporting history of abortion in women with NAFLD was higher than in those without NAFLD (72.4% vs. 69.3%, age-adjusted P = .001). Compared with women without a history of abortion, the fully adjusted odds ratio (OR) for NAFLD in those with a history of abortion was increased by 28% (OR, 1.28 and 95% confidence interval CI], 1.06–1.55). Histories of miscarriage and induced abortion were also associated with increased risk of prevalent NAFLD in fully adjusted models (OR, 1.84 and 95% CI, 1.24–2.72; OR, 1.23 and 95% CI, 1.02–1.50, respectively).ConclusionsBoth miscarriage and induced abortion are associated with prevalent NAFLD in middle-aged and elderly Chinese women. |
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