Maternal fat intake during pregnancy and wheeze and eczema in Japanese infants: the Kyushu Okinawa Maternal and Child Health Study |
| |
| Authors: | Yoshihiro Miyake Keiko Tanaka Hitomi Okubo Satoshi Sasaki Masashi Arakawa |
| |
| Institution: | 1. Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain;2. Department of Experimental and Health Science, Pompeu Fabra University, Barcelona, Spain;3. National School of Public Health, Athens, Greece;4. CIBER Epidemiología y Salud Pública (CIBERESP), Spain;5. IMIM (Hospital del Mar Research Institute), Barcelona, Spain;6. Service of Obstetrics and Gynecology, Hospital Universitari Parc de Salut Mar, Auniversitat Autònoma de Barcelona, Barcelona, Spain;7. Department of Social Medicine, Medical School, University of Crete, Heraklion, Greece;8. Paediatric Cardiology, Great Ormond Street Hospital, London, UK;9. Biodetection Systems B.V., Amsterdam, The Netherlands;10. National Institute for Health and Welfare (THL), Kuopio, Finland;1. Division of Mental Health, Norwegian Institute of Public Health, P.O. Box 4404 Nydalen, 0403 Oslo, Norway;2. Departments of Epidemiology and Nutrition, Gillings School of Global Public Health, University of North Carolina Chapel Hill, CB#7435, Chapel Hill, NC, USA;3. Institute of Psychiatry, University of Oslo, Postboks 1039 Blinderen, 0315 Oslo, Norway;4. Departments of Psychiatry and Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA;1. Department of Animal Science, South Dakota State University, Brookings, SD 57007, United States;2. West Central Research and Extension Center, University of Nebraska-Lincoln, North Platte, NE 69101, United States;3. Department of Animal and Food Sciences, Texas Tech University, Lubbock, TX 79409, United States |
| |
| Abstract: | PurposeThis cohort study examined the relationship between maternal intake of individual fatty acids, meat, and fish during pregnancy and the risk of wheeze and eczema in children aged 23–29 months because epidemiologic evidence on this topic is inconclusive.MethodsSubjects were 1354 Japanese mother-child pairs. Data on maternal intake during pregnancy were assessed with a validated diet history questionnaire. Data on symptoms of wheeze and eczema were based on criteria of the International Study of Asthma and Allergies in Childhood.ResultsSignificant inverse exposure-response relationships were observed between maternal intake of eicosapentaenoic acid (EPA) and EPA plus docosahexaenoic acid (DHA) during pregnancy and infantile wheeze although the adjusted odds ratios between extreme quartiles fell just short of the significance level. No such inverse relationships were detected for infantile eczema. Maternal intake of total fat, saturated fatty acids, monounsaturated fatty acids, total n-3 polyunsaturated fatty acids (PUFA), α-linolenic acid, DHA, total n-6 PUFA, linoleic acid, arachidonic acid, cholesterol, fish, and meat and the ratio of n-3 to n-6 PUFA consumption were not significantly related to infantile wheeze or eczema.ConclusionsHigher maternal intake of EPA and EPA plus DHA during pregnancy may reduce the risk of infantile wheeze. |
| |
| Keywords: | Docosahexaenoic acid Eczema Eicosapentaenoic acid Intake Japanese Pregnancy Wheezing |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
