The role of growth factors in intestinal regeneration and repair in necrotizing enterocolitis |
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| Authors: | Kathryn J Rowland Pamela M Choi Brad W Warner |
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| Institution: | 1. Division of Pediatric Surgery, St Louis Children''s Hospital, St Louis, One''s Children''s Place; Suite 5540, Missouri 63110;2. Department of Surgery, Washington University School of Medicine, St Louis, Missouri 63110;1. Department of Neurology, Harvard Medical School, Boston, Massachusetts;2. Department of Anesthesiology, Perioperative and Pain Medicine, Division of Critical Care Medicine, 300 Longwood Ave, Bader 627, Boston, Massachusetts 02115;1. Department of Pediatrics, The Children''s Hospital of Philadelphia, CHOP North, Room 1523, 34th and Civic Center Blvd, Philadelphia, Pennsylvania 19104;2. Department of Surgery, The Children''s Hospital of Philadelphia, 34th and Civic Center Blvd, Philadelphia, Pennsylvania 19104;2. Department of Pathology, Wayne State University School of Medicine, Detroit, MI;3. Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, OR;4. Department of Physiology, Wayne State University School of Medicine, Detroit, MI;5. Tumor Microenvironment Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI;1. Department of Psychiatry and Behavioral Sciences, Children''s National Medical Center, 111 Michigan Ave NW, Washington, DC 20010;2. Mayo Clinic College of Medicine, Rochester, Minnesota;1. Department of Psychiatry, Boston Children''s Hospital, Boston, Massachusetts;2. Department of Cardiology, Boston Children''s Hospital, Boston, Massachusetts;3. Department of Psychiatry, Harvard Medical School, Boston, Massachusetts;4. Department of Pediatrics, Harvard Medical School, Boston, Massachusetts |
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| Abstract: | Necrotizing enterocolitis (NEC) is a devastating intestinal disease resulting in major neonatal morbidity and mortality. The pathology is poorly understood, and the means of preventing and treating NEC are limited. Several endogenous growth factors have been identified as having important roles in intestinal growth as well as aiding intestinal repair from injury or inflammation. In this review, we will discuss several growth factors as mediators of intestinal regeneration and repair as well as potential therapeutic agents for NEC. |
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